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      Purified Mouse Anti-Striatin
      Purified Mouse Anti-Striatin
      Western blot analysis of Striatin on a rat cerebrum lysate.  Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-Striatin antibody.
      Purified Mouse Anti-Striatin
      Immunofluorescence staining of rat neurons.
      Purified Mouse Anti-Striatin Purified Mouse Anti-Striatin
      Western blot analysis of Striatin on a rat cerebrum lysate.  Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-Striatin antibody.
      Immunofluorescence staining of rat neurons.
      Product Details
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      BD Transduction Laboratories™
      Rat (QC Testing), Human,Mouse,Dog (Tested in Development)
      Mouse IgG2b
      Rat Striatin aa. 450-600
      Western blot (Routinely Tested), Immunofluorescence (Tested During Development)
      110 kDa
      250 µg/ml
      AB_398157
      Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
      RUO


      Preparation And Storage

      The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. Store undiluted at -20°C.
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      Recommended Assay Procedures

      Western blot:  Please refer to http://www.bdbiosciences.com/pharmingen/protocols/Western_Blotting.shtml

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      Product Notices

      1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
      2. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
      3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
      4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
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      610838 Rev. 1
      Antibody Details
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      6/Striatin

      Signal transmission between neurons is regulated by the Ca2+-dependent release of neurotransmitters at the synapse. Striatin is a protein identified in the synaptosomal fraction of rat brain. Reports of sequence homology searches have shown that striatin belongs to a family of proteins with the repeated WD motif (the β-transducin repeat or the WD-40 repeat) found in regulatory proteins. Striatin also binds calmodulin in a Ca2+-dependent manner. Immunolocalization and mRNA expression found striatin in the central nervous system, particularly enriched in neurons of the striatum and motor neurons. Furthermore, subcellular localization studies indicated that Striatin is tightly associated with the plasma membrane. Thus, striatin may play an important role in the Ca2+-dependent events occurring at the synapse.

      610838 Rev. 1
      Format Details
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      Purified
      Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
      Purified
      610838 Rev.1
      Citations & References
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      Development References (2)

      1. Castets F, Bartoli M, Barnier JV. A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons. J Cell Biol. 1996; 134(4):1051-1062. (Biology). View Reference
      2. Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. J Biol Chem. 2000; 275(26):19970-19977. (Biology: Western blot). View Reference
      610838 Rev. 1

      Please refer to Support Documents for Quality Certificates


      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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