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Multiparameter flow cytometric analysis of SLAMF6 (CD352) expression on human peripheral blood leucocyte populations. Whole blood cells were stained with either PE Mouse IgG1, κ Isotype Control (Cat. No. 554680; Left Plot) or PE Mouse Anti-Human SLAMF6 (CD352) antibody (Cat. No. 566378; Right Plot). Erythrocytes were lysed with BD Pharm Lyse™ Lysing Buffer (Cat. No. 555899). Two-parameter flow cytometric contour plots showing the correlated expression of SLAMF6 (CD352) [or Ig Isotype control staining] versus side light-scatter (SSC-A) signals were derived from gated events with the forward and side light-scatter characteristics of viable leucocyte populations. Flow cytometric analysis was performed using a BD™ Canto II Flow Cytometer System.
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BD Pharmingen™ PE Mouse Anti-Human SLAMF6 (CD352)
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Preparation And Storage
Product Notices
- This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-µl experimental sample (a test).
- An isotype control should be used at the same concentration as the antibody of interest.
- Source of all serum proteins is from USDA inspected abattoirs located in the United States.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- For fluorochrome spectra and suitable instrument settings, please refer to our Multicolor Flow Cytometry web page at www.bdbiosciences.com/colors.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
Companion Products





The hSF6.4.20 monoclonal antibody specifically binds to SLAM family member 6 (SLAMF6) which is also known as CD352, NK-T-B-antigen (NTB-A), or Activating NK receptor. CD352 is a ~60 kDa type I transmembrane glycoprotein that contains two ITSMs (immunoreceptor tyrosine-based switch motifs) in its cytoplasmic domain and belongs to the CD2 subfamily of the immunoglobulin superfamily. CD352 is expressed by thymocytes, NK cells, B cells, and T cells. CD352 functions through homophilic interactions as a coreceptor for the activation of NK cells and lymphocytes. It plays roles in regulating various cellular effector functions including cytolytic activity, production of cytokines such as IFN-γ and IL-17, and immunoglobulin class switching.

Development References (6)
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Chatterjee M, Hedrich CM, Rauen T, Ioannidis C, Terhorst C, Tsokos GC. CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.. J Biol Chem. 2012; 287(45):38168-77. (Biology). View Reference
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Eissmann P, Watzl C.. Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells.. J Immunol. 2006; 177(5):3170-3177. (Biology). View Reference
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Flaig RM, Stark S, Watzl C.. Cutting edge: NTB-A activates NK cells via homophilic interaction. J Immunol. 2004; 172(11):6424-6427. (Biology). View Reference
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Kumar KR, Li L, Yan M, et al. Regulation of B cell tolerance by the lupus susceptibility gene Ly108. Science. 2006; 312(5780):1606-1608. (Biology). View Reference
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Ramirez PW, DePaula-Silva AB, Szaniawski M, Barker E, Bosque A, Planelles V. HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins.. Retrovirology. 2015; 12:65. (Biology). View Reference
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Valdez PA, Wang H, Seshasayee D, et al. NTB-A, a new activating receptor in T cells that regulates autoimmune disease.. J Biol Chem. 2004; 279(18):18662-18669. (Biology). View Reference
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