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FITC Mouse Anti-Human CD41a
Product Details
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ITGA2B; Integrin alpha-2b (αIIb); Platelet glycoprotein IIb (GPIIb)
Mouse BALB/c IgG1, κ
Purified platelet membrane glycoproteins
Flow cytometry
25 μg/mL
20 μL
IV P38
Phosphate buffered saline with gelatin and 0.1% sodium azide.

Preparation And Storage

Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.

340929 Rev. 1
Antibody Details
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The CD41a antibody, clone HIP8, is derived from the hybridization of P3X63 mouse myeloma cells with spleen cells isolated from BALB/c mice immunized with purified platelet membrane glycoproteins.

The CD41a antibody recognizes the calcium-dependent gpIIb/IIIa complex, with a molecular weight of 140 kilodaltons (kDa).

340929 Rev. 1
Format Details
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Fluorescein (FITC) is part of the BD blue family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 494-nm and an emission maximum (Em Max) at 518-nm. FITC is designed to be excited by the Blue laser (488-nm) and detected using an optical filter centered near 520 nm (e.g., a 530/30-nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
Blue 488 nm
494 nm
518 nm
340929 Rev.1
Citations & References
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Development References (12)

  1. Bettaieb A, Fromont P, Louache F, et al. Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura. Blood. 1992; 80:162-169. (Biology).
  2. Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
  3. Chen CS, Thiagarajan P, Schwartz SM, Harlan JM, Heimark RL. The platelet glycoprotein IIb/IIIa-like protein in human endothelial cells, promotes adhesion but not initial attachment to extracellular matrix. J Cell Biol. 1987; 105:1885-1892. (Biology).
  4. Clinical and Laboratory Standards Institute. 2005. (Biology).
  5. Feng R, Shimazaki C, Inaba T, et al. CD34+/CD41a+ cells best predict platelet recovery after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1998; 21:1217-1222. (Biology).
  6. Jennings LK, Ashmun RA, Wang WC, Docter ME. Analysis of human platelet glycoproteins IIb-IIIa and Glanzmann’s thrombasthenia in whole blood by flow cytometry. Blood. 1986; 68:173-179. (Biology).
  7. Kitagawa M, Yoshida S, Ishige I, et al. Immunolocalization of platelet-derived growth factor, transforming growth factor-β, and fibronectin in acute megakaryoblastic leukemia manifesting tumor formation. Human Pathol. 1994; 25:723-726. (Biology).
  8. Phillips DR, Charo IF, Parise LV, Fitzgerald LA. The platelet membrane glycoprotein IIb-IIIa complex. Blood. 1988; 71:831-843. (Biology).
  9. Spangenberg P, Redlich H, Bergmann I, Lösche W, Götzrath M, Kehrel B. The platelet glycoprotein IIb/IIIa complex is involved in the adhesion of activated platelets to leukocytes. Thromb Haemos. 1993; 70:514-521. (Biology).
  10. Yasunaga M, Ryo R, Konaka Y, et al. Extramedullary tumor as presentation of leukemia: establishment of a new human gpIIb- and gpIIIa-positive leukemia cell line. Ann Hematol. 1994; 68:145-151. (Biology).
  11. de Haas M, von dem Borne A. CD41/CD61 Workshop Panel report. In: Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:643-645.
  12. von dem Borne AEGKr, Modderman PW, Admiraal LG, Nieuwenhuis, HK. Platelet antibodies, the overall results. In: Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:951-966.
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340929 Rev. 1

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