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BD Transduction Laboratories™ Purified Mouse Anti-LR11
Clone 48/LR11 (RUO)
Western blot analysis of LR11 on a rat cerebrum lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-LR11 antibody.
Western blot analysis of LR11 on a rat cerebrum lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-LR11 antibody.
Product Details
BD Transduction Laboratories™
SorLA; gp250; Lipoprotein Receptor-11
Rat (QC Testing), Human, Mouse (Tested in Development)
Mouse IgG2a
Human LR11 aa. 1220-1337
Western blot (Routinely Tested), Immunofluorescence (Not Recommended)
250 kDa
250 µg/ml
AB_399341
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
RUO
Preparation And Storage
Store undiluted at -20°C. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Recommended Assay Procedures
Western blot: Please refer to http://www.bdbiosciences.com/pharmingen/protocols/Western_Blotting.shtml
Product Notices
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- Source of all serum proteins is from USDA inspected abattoirs located in the United States.
612633 Rev. 1
Antibody Details
48/LR11
The low-density lipoprotein receptor (LDLR) functions in lipoprotein transport pathways, and is involved in familial hypercholesterolemia. Homologues of the LDLR may have diverse functions and their ligands may include biological inactive plasma carrier complexes, plasma lipoproteins, yolk precursors, toxins, and extracellular lipoproteins. LR11 (also known as sorLA-1 and gp250) is a lipoprotein receptor homologue that contains 11 LDL receptor ligand binding repeats (LDLRs), 5 LDL receptor "YWTD"repeats, a large fibronectin-type III (FIII) hexarepeat domain similar to neural adhesion proteins, and a domain with similarity to the yeast receptor for vacuolar protein sorting (Vsp10p). LR11mRNA is expressed at high levels in brain, but is also found in liver, pancreas, adrenal gland, and testis. LR11 can bind the ER and Golgi localized receptor associated protein (RAP), which binds to many members of the LDLR family and prevents aggregation of ligands to the LDLRs. In addition, LR11 binds apolipoprotein E-containing lipoproteins. Thus, LR11 is a lipoprotein binding receptor that may have additional functions related to protein sorting and neuronal development.
612633 Rev. 1
Format Details
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
Purified
612633 Rev.1
Citations & References
View product citations for antibody "612633" on CiteAb
Development References (3)
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Jacobsen L, Madsen P, Moestrup SK. Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. J Biol Chem. 1996; 271(49):31379-31383. (Biology). View Reference
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Posse De Chaves EI, Vance DE, Campenot RB, Kiss RS, Vance JE. Uptake of lipoproteins for axonal growth of sympathetic neurons. J Biol Chem. 2000; 275(26):19883-19890. (Biology). View Reference
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Yamazaki H, Bujo H, Kusunoki J. Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member. J Biol Chem. 1996; 271(40):24761-24768. (Biology). View Reference
612633 Rev. 1
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.