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Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Human lymphocytes may be classified in three main populations according to their biological function and their cell surface antigen expression: T lymphocytes, B lymphocytes and Natural Killer cells (NK). Most B cells, with the exception of pre-B progenitors, pre-B cells, and mature plasma cells, express immunoglobulin on their surface. Each cell expresses only one Light Chain type. In normal peripheral blood and lymph nodes, there is a mixture of Kappa positive and Lambda positive cells, with two-thirds of the cells expressing Kappa and one-third expressing Lambda. Since lymphoid neoplasms are usually clonal expansions of a single cell, malignant cells uniformly express the same Light Chain isotype. Neoplastic B cell lymphoprolipherative disorders can frequently be suspected on the basis of the demonstration of a marker predominance of cells expressing a single Light Chain type.
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Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For In Vitro Diagnostics Use.
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