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LAMBDA-FITC / KAPPA-PE

BD Cytognos™ LAMBDA-FITC / KAPPA-PE

Clone PolyLambda+Kappa

(IVD)
Product Details
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BD Cytognos™
Human
Goat BALB/c IgG2a, Mixed
Human B-cells (except pre-B progenitors, pre-B cells)
10 µl/test
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IVD


cyt-lf-kpe-100 Rev. 1
Antibody Details
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PolyLambda+Kappa

Human lymphocytes may be classified in three main populations according to their biological function and their cell surface antigen expression: T lymphocytes, B lymphocytes and Natural Killer cells (NK). Most B cells, with the exception of pre-B progenitors, pre-B cells, and mature plasma cells, express immunoglobulin on their surface. Each cell expresses only one Light Chain type. In normal peripheral blood and lymph nodes, there is a mixture of Kappa positive and Lambda positive cells, with two-thirds of the cells expressing Kappa and one-third expressing Lambda. Since lymphoid neoplasms are usually clonal expansions of a single cell, malignant cells uniformly express the same Light Chain isotype. Neoplastic B cell lymphoprolipherative disorders can frequently be suspected on the basis of the demonstration of a marker predominance of cells expressing a single Light Chain type.

cyt-lf-kpe-100 Rev. 1
Citations & References
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View product citations for antibody "cyt-lf-kpe-100" on CiteAb
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cyt-lf-kpe-100 Rev. 1

 

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For In Vitro Diagnostics Use.

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