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Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation And Storage
Recommended Assay Procedures
For optimal and reproducible results, BD Horizon Brilliant Stain Buffer should be used anytime two or more BD Horizon Brilliant dyes (including BD OptiBuild Brilliant reagents) are used in the same experiment. Fluorescent dye interactions may cause staining artifacts which may affect data interpretation. The BD Horizon Brilliant Stain Buffer was designed to minimize these interactions. More information can be found in the Technical Data Sheet of the BD Horizon Brilliant Stain Buffer (Cat. No. 563794).
Product Notices
- This antibody was developed for use in flow cytometry.
- The production process underwent stringent testing and validation to assure that it generates a high-quality conjugate with consistent performance and specific binding activity. However, verification testing has not been performed on all conjugate lots.
- Researchers should determine the optimal concentration of this reagent for their individual applications.
- An isotype control should be used at the same concentration as the antibody of interest.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- For fluorochrome spectra and suitable instrument settings, please refer to our Multicolor Flow Cytometry web page at www.bdbiosciences.com/colors.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- BD Horizon Brilliant Stain Buffer is covered by one or more of the following US patents: 8,110,673; 8,158,444; 8,575,303; 8,354,239.
- BD Horizon Brilliant Blue 700 is covered by one or more of the following US patents: 8,455,613 and 8,575,303.
- Cy is a trademark of GE Healthcare.
Companion Products
The 421203 monoclonal antibody specifically recognizes Claudin-1 which is also known as Senescence-associated epithelial membrane protein 1 (SEMP1) or Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC). Claudin-1 is a ~23 kDa multi-pass membrane protein that is encoded by CLDN1 (claudin 1) which belongs to the claudin family. Claudin-1 is expressed by Langerhans cells, dendritic cells, epithelial cells and endothelial cells. It serves as a major component of tight junctions between epithelial or endothelial cells. Claudin-1 may also function as a co-receptor for Hepatitis C virus (HCV) entry into hepatic cells. Dysregulated Claudin-1 expression has been detected in multiple types of cancer.
Development References (2)
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Farquhar MJ, Hu K, Harris HJ, et al. Hepatitis C virus induces CD81 and claudin-1 endocytosis.. J Virol. 2012; 86(8):4305-16. (Clone-specific: Immunocytochemistry). View Reference
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Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin.. J Cell Biol. 1998; 141(7):1539-50. (Biology). View Reference
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.