A Multi-omics Approach to Investigate the Heterogeneity of Memory T cells
March 29, 2022
The post-thymic activation and development of T cells involves a heterogeneous population of cells at different stages of differentiation, including naïve, stem cell memory, central memory, effector memory and terminal effector T cells. These different T-cell subsets are themselves highly heterogeneous, and their identification and characterization require not one or a few but, rather, a combination of several markers. Researchers are now seeking new markers that might provide insights into the T-cell differentiation and development pathway and potentially identify new cell populations. These exploratory studies require development of multi-omics approaches that combine high-dimensional flow cytometry and single-cell RNA sequencing (scRNA-Seq) for phenotypic and genomic analyses at the single-cell level.
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