The Evolution of the BD FACSLyric™ System: A Journey Through Innovation

The BD FACSLyric™ Flow Cytometry System has become a cornerstone in clinical and research laboratories worldwide. Its journey from inception to the present day is a testament to continuous innovation and dedication to improving cell analysis. Let’s explore the history, features, and advancements of this remarkable system.

A Brief History

The BD FACSLyric™ system was introduced by BD Biosciences as a next-generation flow cytometer designed to meet the evolving needs of clinical laboratories. Building on decades of expertise in flow cytometry, BD aimed to create a system that combined simplicity, speed and automation to enhance laboratory productivity and accuracy.

Key Features and Initial Launch

When the BD FACSLyric™ system was first launched, it brought several groundbreaking features to the table:

• High Sensitivity and Resolution: The system was designed to deliver exceptional sensitivity and resolution, making it easier to detect dim and rare cell populations
• Flexibility: It offered multiple configurations (4-, 6-, 8-, 10-color options) and was upgradeable on-site to adapt to changing laboratory needs. Assay portability helps cross-laboratory
• Automation: The BD FACSLyric™ system integrated automation features such as automated single-tube quality control (QC) with BD™ CS&T beads and automated compensation through the universal setup which eliminates time consuming compensation runs, all in mind to reduce the need for frequent manual interventions and standardize as much as possible the usage of the system
• Reduced Maintenance: Fluorescence compensation, which initially required frequent adjustments, was optimized to be needed only every 60 days, significantly improving efficiency
• One integrated system for standardized workflows that accommodates CE-IVD and user-defined assays

Improvements Over Time

Over the years, BD has continued to enhance the FACSLyric™ system, incorporating feedback from users and advancements in technology. Some notable improvements include:

• Increased Throughput: The system’s maximum acquisition rate was increased to 35,000 events per second, allowing for rapid data collection without compromising quality
• Enhanced Software: The BD FACSuite™ software was continuously updated to improve user experience, data analysis, and it transitioned to IVDR compliance. Latest software version includes BD ElastiGate™ Technology that reduces the need for manual gating while allowing manual adjustments to the results. This technology reduces error-prone manual gating, boosts standardization and allows to analyze the data 18X faster than manual analysis. More information: BD FACSuite™ Application | BD Biosciences
• Bi-directional communication of test and patient data between BD FACSLyric™ and Laboratory Information System through the BD FACS™ Workflow Manager middleware solution
• Continuous expansion of available CE-IVD assays validated for use on the BD FACSLyric™ instrument. The BD FACSLyric™ instrument transitioned also towards IVDR compliance

Current Capabilities

Today, the BD FACSLyric™ system stands as a highly reliable and versatile tool in flow cytometry. Its current capabilities include:

• Multi-Laser Configurations: The system supports up to three lasers (blue, red and violet) and 12 fluorescence channels, providing comprehensive analysis options
• Minimal Sample Carryover: With advanced sample injection tube (SIT) flush techniques, the system ensures minimal sample carryover, enhancing accuracy
• Broad Application Range: From clinical diagnostics to research applications, the BD FACSLyric™ system is used in various fields, including immunology, oncology, and infectious diseases
• Integrated clinical flow cytometry solution that simplifies and automates processes, with traceability and electronic audit trails, helping to drive compliance, automation, standardisation and quality
• Seamless integration with the BD FACSDuet™ Sample Preparation System that provides a complete walkaway workflow solution for Lyse Wash and Lyse no Wash applications

Conclusion

The BD FACSLyric™ Flow Cytometry System has evolved significantly since its introduction. Its blend of high performance, flexibility, and automation has made it an indispensable tool in laboratories around the world. As BD Biosciences continues to innovate, we can expect even more advancements that will further enhance the capabilities and applications of the BD FACSLyric™ system in the future.

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