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PerCP Mouse Anti-Human CD42a
Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation And Storage
Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.
The CD42a antibody, clone Beb1, is derived from hybridization of Sp2/0 mouse myeloma cells with spleen cells from BALB/c mice immunized with normal human platelets. The CD42a antibody recognizes a 17 to 22-kilodalton (kDa) single-chain, platelet membrane glycoprotein, also known as gpIX that forms a noncovalent complex with gpIb and gpV. Glycoprotein Ib consists of an α–chain disulfide-linked to a β chain. Glycoproteins Ibα (140 to 145 kDa), Ibβ (24 to 25 kDa), and V (82 to 86 kDa) have been designated as CD42b, CD42c and CD42d respectively. CD42a has been reported to react with both gpIX and the gpIb-IX-V complex.
Development References (15)
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Nieuwenhuis HK. Report on functional studies. In: Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:1002-1003.
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Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
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Clinical and Laboratory Standards Institute. 2005. (Biology).
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Du X, Beutler L, Ruan C, Castaldi PA, Berndt MC. Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane.. Blood. 1987; 69(5):1524-7. (Biology). View Reference
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Fox JE, Aggerbeck LP, Berndt MC. Structure of the glycoprotein Ib.IX complex from platelet membranes. J Biol Chem. 1988; 263(10):4882-4890. (Biology). View Reference
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Hickey MJ, Williams SA, Roth GJ. Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures. Proc Natl Acad Sci U S A. 1989; 86(17):6773-6777. (Biology). View Reference
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Hourdillé P, Heilmann E, Combrié R, Winckler J, Clemetson KJ, Nurden AT. Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane systems of activated human platelets.. Blood. 1990; 76(8):1503-13. (Biology). View Reference
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Michelson AD, Benoit SE, Furman MI, Barnard MR, Nurden P, Nurden AT. The platelet surface expression of glycoprotein V is regulated by two independent mechanisms: proteolysis and a reversible cytoskeletal-mediated redistribution to the surface-connected canalicular system.. Blood. 1996; 87(4):1396-408. (Biology). View Reference
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Michelson AD, Benoit SE, Kroll MH, et al. The activation-induced decrease in the platelet surface expression of the glycoprotein Ib-IX complex is reversible.. Blood. 1994; 83(12):3562-73. (Biology). View Reference
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Michelson AD, Ellis PA, Barnard MR, Matic GB, Viles AF, Kestin AS. Downregulation of the platelet surface glycoprotein Ib-IX complex in whole blood stimulated by thrombin, adenosine diphosphate, or an in vivo wound.. Blood. 1991; 77(4):770-9. (Biology). View Reference
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Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE. Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane.. J Biol Chem. 1992; 267(1):364-9. (Biology). View Reference
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Ruggeri ZM. The platelet glycoprotein Ib-IX complex.. Prog Hemost Thromb. 1991; 10:35-68. (Biology). View Reference
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Silverstein RL. Schlossman S, Boumsell L, Gilks W, ed. Leucocyte Typing V: White Cell Differentiation Antigens. New York, NY: Oxford University Press; :995:1197.
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Yamamoto N, Greco NJ, Barnard MR, et al. Glycoprotein Ib (GPIb)-dependent and GPIb-independent pathways of thrombin-induced platelet activation.. Blood. 1991; 77(8):1740-8. (Biology). View Reference
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von dem Borne AEGKr, Modderman PW. Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:1000-1002.
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Although not required, these products are manufactured in accordance with Good Manufacturing Practices.