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PE Mouse Anti-Human CD64
Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
The CD64 antibody, clone 10.1, is derived from the hybridization of Sp2/0-Ag14 mouse myeloma cells with spleen cells isolated from a BALB/c mouse that was immunized first with 2 x 107 rheumatoid synovial fluid cells and on subsequent occasions with 1.5 x 107 fibronectin-purified human monocytes obtained from pools of blood group–matched donors.
CD64 recognizes the 72-kilodalton (kDa) human FcγRI that can bind monomeric IgG.
Development References (11)
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Davis BH, Bigelow NC, Curnutte JT, Ornvold K. Neutrophil CD64 expression: potential diagnostic indicator of acute inflammation and therapeutic monitor of interferon-γ therapy. Lab Hematol. 1995; 1:3-12. (Biology).
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Dougherty GJ, Selvendran Y, Murdoch S, Palmer DG, Hogg N. The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1. Eur J Immunol. 1987; 17(10):1453-1459. (Biology). View Reference
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Ernst LK, van de Winkel JGJ, Chiu IM, Anderson CL. Three genes for the human high affinity Fc receptor for IgG (Fc γ RI) encode four distinct transcription products. J Biol Chem. 1992; 267:15692-15700. (Biology).
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Fanger NA, Wardwell K, Shen L, Tedder TF, Guyre PM. Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells.. J Immunol. 1996; 157(2):541-8. (Biology). View Reference
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Gosselin EJ, Wardwell K, Gosselin DR, Alter N, Fisher JL, Guyre PM. Enhanced antigen presentation using human Fc γ receptor (monocyte/macrophage)–specific immunogens. J Immunol. 1992; 149:3477-3481. (Biology).
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Olweus J, Terstappen LW, Thompson PA, Lund-Johansen F. Expression and function of receptors for stem cell factor and erythropoietin during lineage commitment of human hematopoietic progenitor cells. Blood. 1996; 88:1594-1607. (Biology). View Reference
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Valerius T, Repp R, de Wit TP, et al. Involvement of the high-affinity receptor for IgG (Fc γ RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy. Blood. 1993; 82:931-939. (Biology).
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van Vugt MJ, Heijnen IAFM, Capel PJ, et al. FcR γ-chain is essential for both surface expression and function of human Fc γ RI (CD64) in vivo. Blood. 1996; 87:3593-3599. (Biology).
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van de Winkel JG, Anderson CL. Biology of human immunoglobulin G Fc receptors.. J Leukoc Biol. 1991; 49(5):511-24. (Biology). View Reference
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van de Winkel JG, Capel PJ. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications.. Immunol Today. 1993; 14(5):215-21. (Biology). View Reference
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van de Winkel JG, Ernst LK, Anderson CL, Chiu IM. Gene organization of the human high affinity receptor for IgG, Fc γ RI (CD64). Characterization and evidence for a second gene. J Biol Chem. 1991; 266:13449-13455. (Biology).
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Although not required, these products are manufactured in accordance with Good Manufacturing Practices.