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      FITC Mouse Anti-Human IL-1α
      Product Details
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      BD FastImmune™
      Human
      Mouse BALB/c IgG1, κ
      Human
      Intracellular staining (flow cytometry)
      6.3 μg/mL
      20 μL
      3552
      Phosphate buffered saline with gelatin and 0.1% sodium azide.
      RUO (GMP)


      Preparation And Storage

      Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.

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      340513 Rev. 1
      Antibody Details
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      AS5

      The Anti-Hu–IL-1α antibody, clone AS5, is derived from fusion of P3X63Ag8 myeloma cells with splenocytes from BALB/c mice immunized with recombinant human IL-1α.

      The Anti-Human Interleukin-1α (Anti-Hu–IL-1α) antibody recognizes a 13- to 18-kilodalton (kDa) polypeptide.

      340513 Rev. 1
      Format Details
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      FITC
      Fluorescein (FITC) is part of the BD blue family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 494-nm and an emission maximum (Em Max) at 518-nm. FITC is designed to be excited by the Blue laser (488-nm) and detected using an optical filter centered near 520 nm (e.g., a 530/30-nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
      altImg
      FITC
      Blue 488 nm
      494 nm
      518 nm
      340513 Rev.1
      Citations & References
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      View product citations for antibody "340513" on CiteAb

      Development References (14)

      1. Centers for Disease Control. Perspectives in disease prevention and health promotion update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings. MMWR. 1988; 37:377-388. (Biology).
      2. Clinical and Laboratory Standards Institute. 2005. (Biology).
      3. Conlon PJ, Grabstein KH, Alpert A, et al. Localization of human mononuclear cell interleukin 1. J Immunol. 1987; 139:98-102. (Biology).
      4. Dinarello CA. Biology of interleukin 1. FASEB J. 1988; 2:108-115. (Biology).
      5. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood. 1991; 77(8):1627-1652. (Biology). View Reference
      6. Fini ME, Strissel KJ, Girard MT, Mays JW, Rinehart WB. Interleukin 1αmediates collegenase synthesis stimulated by Phorbol 12-Myristate 13-Acetate. J Bio Chem. 1994; 269:11291-11298. (Biology).
      7. Giri JG, Lomedico PT, Mizel SB. Studies on the synthesis and secretion of interleukin 1. I. A 33,000 molecular weight precursor for interleukin 1. J Immunol. 1985; 134(1):343-349. (Biology). View Reference
      8. Mantovani A, Dejana E. Cytokines as communication signals between leukocytes and endothelial cells. J Immunol. 1989; 10:370-375. (Biology).
      9. Matsushima K, Yodoi J, Tagaya Y, Oppenheim JJ. Downregulation of interleukin-1 receptor expression by IL-1 and fate of internalized125 I-labeled IL-1 β in a human large granular lymphocyte cell line. J Immunol. 1986; 137:3183-3188. (Biology).
      10. Mizel SB. The interleukins. FASEB J. 1989; 32379-2388. (Biology).
      11. Saklatvala J. Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Science. 1986; 322:547-549. (Biology).
      12. Slack J, McMahan CJ, Waugh S. et al. Independent binding of interleukin-1 α and interleukin-1 β to type I and type II interleukin 1 receptors. J Bio Chem. 1993; 268:2513-2524. (Biology).
      13. Van Zee KJ, DeForge LE, Fischer E, et al. IL-8 in septic shock, endotoxemia and after IL-1 administration. J Immunol. 1991; 146:3478-3482. (Biology).
      14. West-Mays JA, Strissel KJ, Sadow PM, Fini ME. Competence for collegenase gene expression by tissue fibroblasts requires activation of an interleukin 1α autocrine loop. Prod Natl Acad Sci. 1995; 92:6768-6772. (Biology).
      View All (14) View Less
      340513 Rev. 1

       

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      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures. 

       

      Although not required, these products are manufactured in accordance with Good Manufacturing Practices.