-
Your selected country is
Luxembourg
- Change country/language
Old Browser
This page has been recently translated and is available in French now.
Looks like you're visiting us from {countryName}.
Would you like to stay on the current country site or be switched to your country?
Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation And Storage
The PE conjugate is supplied in 1.0 mL of PBS containing gelatin and 0.1% sodium azide. You may wish to titer the reagent for use in your specific application. Refer to the vial label for antibody concentration. The vial should be stored at 2° to 8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.
CD134, clone L106, is derived from hybridization of mouse Sp2/0 cells with spleen cells from BALB/c mice immunized with phytohemagglutinin-activated T lymphocytes. CD134 (Anti-Human Ox 40) recognizes a 50-kdalton (kDa) antigen that is present on activated T lymphocytes. By sequence analysis, it is related to the rat monoclonal antibody Ox 40, a member of the nerve growth factor superfamily that also includes CD27, CD30, CD40, CD95 (Fas), and the tumor necrosis factors alpha and beta (CD120a and CD120b).
Development References (7)
-
Barclay AN, Birkeland ML, Brown MH, et al. 1993.
-
Fanslow WC, Clifford KN, Zappone J, Sorensen R, Gaum P. Involvement of Ox40 interaction in murine cardiac allograft rejection. 1995; 575a. (Biology).
-
Godfrey W, Buck D, Harara M, Benike C, Engleman E. Studies of the L106 protein and its gene: Evidence that L106 and Ox 40 are homologous. In: Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995:1157-1160.
-
Godfrey WR, Fagnoni FF, Harara MA, Buck D, Engleman EG. Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. J Exp Med. 1994 August; 180(2):757-762. (Biology). View Reference
-
Mallett S, Fossum S, Barclay AN. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor. EMBO J. 1990; 9(4):1063-1068. (Biology). View Reference
-
Paterson DJ, Jefferies WA, Green JR, et al. Antigens of activated rat lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T cell blasts. Mol Immunol. 1993; 24:1282. (Biology).
-
Tittle TV, Steinkeler C, Weinberg A, Maziarz R. The expression of the T cell activation antigen, Ox-40, in GVHD. Blood. 1995; 86(10):575a-576a. (Biology).
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Although not required, these products are manufactured in accordance with Good Manufacturing Practices.