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Explore our products against C1q available for RUO use. These antibodies can be used for applications such as flow cytometry against Mouse targets. Our C1q antibodies were developed in Mouse and Rat and have Mouse IgG2b and Rat IgG1 κ isotypes. Review multiple figures from product development to select the best reagents for your needs.
Description: Involved in several processes, including complement-mediated synapse pruning; microglial cell activation; and nervous system development. Acts upstream of or within complement activation, classical pathway. Located in postsynapse. Is expressed in brain; foot; genitourinary system; and pancreas. Used to study epilepsy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human C1QA (complement C1q A chain).
Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Molecular Function: Complement pathway, Immunity, Innate immunity
Subcellular location: secreted
kDa: 26
C1q; AdicNA
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
