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      Purified Mouse Anti-La Protein
      Purified Mouse Anti-La Protein
      Western blot analysis of La Protein on HCT-8 lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of anti-La Protein antibody.
      Purified Mouse Anti-La Protein
      Immunofluorescent staining of HeLa cells.
      Purified Mouse Anti-La Protein Purified Mouse Anti-La Protein
      Western blot analysis of La Protein on HCT-8 lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of anti-La Protein antibody.
      Immunofluorescent staining of HeLa cells.
      商品详情
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      BD Transduction Laboratories™
      Human (QC Testing), Rat, Dog, Rabbit (Tested in Development)
      Mouse IgG1
      Human La Protein aa. 179-289
      Western blot (Routinely Tested), Immunofluorescence (Tested During Development)
      47 kDa
      250 µg/ml
      Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
      RUO


      商品通知

      1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
      2. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
      3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
      4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
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      610904 Rev. 1
      抗体详情
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      44/La Protein

      La was first found to bind autoantibodies from individuals with Sjogren's syndrome and systemic lupus erythematosus (SLE). La is a transcription factor for RNA polymerase III (Pol III). It participates in the termination of Pol III-mediated transcription and the recycling of the transcriptional machinery. La associates with the 3' oligo U portion of transcripts generated by Pol III. In some cases, this association protects the message from 3' processing. The association of La and mRNA is mediated by the presence of an N-terminal ribonucleoprotein (RNP) consensus sequence in La. The La protein also binds several small RNAs, such as 7S RNA, 5S RNA, and tRNA, and is thought to be involved in their biogenesis. It is known that histone mRNA is stabilized throughout S Phase and is degraded only at the end of S phase. La protein participates in the stabilization of histone mRNA which results in increased production of histone protein. These data suggest that a major function of La is to protect vital nascent transcripts from premature degradation.

      610904 Rev. 1
      格式详情
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      Purified
      Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
      Purified
      610904 Rev.1
      报价单和参考
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      研发参考 (3)

      1. Chambers JC, Kenan D, Martin BJ, Keene JD. Genomic structure and amino acid sequence domains of the human La autoantigen. J Biol Chem. 1988; 263(34):18043-18051. (Biology). 查看参考
      2. Goodier JL, Fan H, Maraia RJ. A carboxy-terminal basic region controls RNA polymerase III transcription factor activity of human La protein. Mol Cell Biol. 1997; 17(10):5823-5832. (Biology). 查看参考
      3. McLaren RS, Caruccio N, Ross J. Human La protein: a stabilizer of histone mRNA. Mol Cell Biol. 1997; 17(6):3028-3036. (Biology). 查看参考
      610904 Rev. 1

      Please refer to Support Documents for Quality Certificates


      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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