Skip to main content Skip to navigation
Hamburger Menu
Search icon
Country Selector Country Selector
China (Chinese)
登录/注册 UserName
产品

Link Arrow
解决方案

Link Arrow
发现&学习

Link Arrow
资源&工具

Link Arrow
Support

Link Arrow
Search icon Search icon
Close Menu
      Alert Icon
      Purified Mouse Anti-Human HLA-DM
      Purified Mouse Anti-Human HLA-DM
      Profile of intracellular staining of peripheral blood lymphocytes analyzed on a FACScan (BDIS, San Jose, CA).
      Purified Mouse Anti-Human HLA-DM
      Profile of intracellular staining of peripheral blood monocytes analyzed on a FACScan (BDIS, San Jose, CA).
      Purified Mouse Anti-Human HLA-DM Purified Mouse Anti-Human HLA-DM
      Profile of intracellular staining of peripheral blood lymphocytes analyzed on a FACScan (BDIS, San Jose, CA).
      Profile of intracellular staining of peripheral blood monocytes analyzed on a FACScan (BDIS, San Jose, CA).
      商品详情
      Down Arrow Up Arrow


      BD Pharmingen™
      Human (QC Testing)
      Mouse IgG1, κ
      Intracellular staining (flow cytometry) (Routinely Tested)
      0.5 mg/ml
      AB_396271
      Aqueous buffered solution containing ≤0.09% sodium azide.
      RUO


      商品通知

      1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
      2. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
      3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
      显示较多信息 blue down arrow 显示较少信息 blue up arrow
      555982 Rev. 5
      抗体详情
      Down Arrow Up Arrow
      MaP.DM1

      Reacts with human leukocyte antigen-DM (HLA-DM), a non-classical MHC class II molecule expressed in the cytoplasm of antigen presenting cells (APC). HLA-DM is composed of alpha and beta subunits which form a similar structure as the classical class II molecules. HLA-DM catalyzes the dissociation of CLIP from MHC class II-CLIP complexes in vitro and facilitates the binding of antigenic peptides. It also prevents self-antigens from becoming stably complexed with class II molecules and being presented to T cells.

      555982 Rev. 5
      格式详情
      Down Arrow Up Arrow
      Purified
      Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
      Purified
      555982 Rev.5
      报价单和参考
      Down Arrow Up Arrow
      View product citations for antibody "555982" on CiteAb

      研发参考 (6)

      1. Denzin LK, Cresswell P. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell. 1995; 82(1):155-165. (Biology). 查看参考
      2. Denzin LK, Hammond C, Cresswell P. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J Exp Med. 1996; 184(186):2153-2165. (Biology). 查看参考
      3. Denzin LK, Robbins NF, Carboy-Newcomb C, Cresswell P. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity. 1994; 1(7):595-606. (Biology). 查看参考
      4. Kropshofer H, Hämmerling GJ, Vogt AB. How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest. Immunol Today. 1997; 18(2):77-82. (Biology). 查看参考
      5. Riberdy JM, Avva RR, Geuze HJ, Cresswell P. Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines. J Cell Biol. 1994; 125(126):1225-1237. (Biology). 查看参考
      6. Riberdy JM, Newcomb JR, Surman MJ, Barbosa JA, Cresswell P. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature. 1992; 360(6403):474-477. (Biology). 查看参考
      查看所有文件 (6) 查看更少内容
      555982 Rev. 5

      Please refer to Support Documents for Quality Certificates

       

      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described

       

      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures.