Preparation and Storage
Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.
The CD41a antibody, clone HIP8, is derived from the hybridization of P3X63 mouse myeloma cells with spleen cells isolated from BALB/c mice immunized with purified platelet membrane glycoproteins. The CD41a antibody recognizes the calcium-dependent gpIIb/IIIa complex, with a molecular weight of 140 kilodaltons (kDa).
Development References (12)
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Bettaieb A, Fromont P, Louache F, et al. Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura. Blood. 1992; 80:162-169. (Biology).
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Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
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Chen CS, Thiagarajan P, Schwartz SM, Harlan JM, Heimark RL. The platelet glycoprotein IIb/IIIa-like protein in human endothelial cells, promotes adhesion but not initial attachment to extracellular matrix. J Cell Biol. 1987; 105:1885-1892. (Biology).
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Clinical and Laboratory Standards Institute. 2005. (Biology).
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Feng R, Shimazaki C, Inaba T, et al. CD34+/CD41a+ cells best predict platelet recovery after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1998; 21:1217-1222. (Biology).
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Jennings LK, Ashmun RA, Wang WC, Docter ME. Analysis of human platelet glycoproteins IIb-IIIa and Glanzmann’s thrombasthenia in whole blood by flow cytometry. Blood. 1986; 68:173-179. (Biology).
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Kitagawa M, Yoshida S, Ishige I, et al. Immunolocalization of platelet-derived growth factor, transforming growth factor-β, and fibronectin in acute megakaryoblastic leukemia manifesting tumor formation. Human Pathol. 1994; 25:723-726. (Biology).
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Phillips DR, Charo IF, Parise LV, Fitzgerald LA. The platelet membrane glycoprotein IIb-IIIa complex. Blood. 1988; 71:831-843. (Biology).
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Spangenberg P, Redlich H, Bergmann I, Lösche W, Götzrath M, Kehrel B. The platelet glycoprotein IIb/IIIa complex is involved in the adhesion of activated platelets to leukocytes. Thromb Haemos. 1993; 70:514-521. (Biology).
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Yasunaga M, Ryo R, Konaka Y, et al. Extramedullary tumor as presentation of leukemia: establishment of a new human gpIIb- and gpIIIa-positive leukemia cell line. Ann Hematol. 1994; 68:145-151. (Biology).
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de Haas M, von dem Borne A. CD41/CD61 Workshop Panel report. In: Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:643-645.
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von dem Borne AEGKr, Modderman PW, Admiraal LG, Nieuwenhuis, HK. Platelet antibodies, the overall results. In: Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:951-966.
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Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Although not required, these products are manufactured in accordance with Good Manufacturing Practices.
