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Purified Mouse Anti-SCP3
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BD Transduction Laboratories™
Synaptonemal Complex Protein-3
Rat (QC Testing), Human, Mouse, Dog, Chicken (Tested in Development)
Mouse IgG1
Rat SCP3 aa. 1-109
Western blot (Routinely Tested), Immunofluorescence (Not Recommended)
34/37 kDa
250 µg/ml
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Product Notices

  1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
  2. Please refer to for technical protocols.
  3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
  4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
611230 Rev. 1
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Division of haploid germ cells during meiosis involves the pairing and recombination of homologous chromosomes. The synaptonemal complex (SC) is a meiotic protein structure that enhances chromosome pairing and segregation, affects the number and distribution of crossovers, and produces functional chiasmata from crossovers. The SC contains a central element (CE) and two lateral elements (LE) that are connected by transverse filaments (TF). Among the various SC components are two mammalian LE proteins, SCP2 and SCP3 (Synaptonemal Complex Proteins 2 and 3). SCP3 is highly similar to two other mammalian proteins, Xlr and Xmr, that are expressed in B and T lymphocytes  and meiotic cells, respectively, and to members of the IF (intermediate filament) protein family. The SCP3 C-terminal region contains multiple coiled-coil domains that mediate protein-protein interactions. Via these domains, SCP3 self-assembles into transversely striated homopolymeric fibers in somatic cells. Such assembly also requires the N-terminal nonhelical domain. This function indicates that SCP3 may serve as an LE molecular scaffold to which other proteins bind and participate in recombination.

611230 Rev. 1
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Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
611230 Rev.1
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Development References (2)

  1. Lammers JH, Offenberg HH, van Aalderen M, Vink AC, Dietrich AJ, Heyting C. The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes. Mol Cell Biol. 1994; 14(2):1137-1146. (Biology). View Reference
  2. Yuan L, Pelttari J, Brundell E, et al. The synaptonemal complex protein SCP3 can form multistranded, cross-striated fibers in vivo. J Cell Biol. 1998; 142(2):331-339. (Biology). View Reference
611230 Rev. 1

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Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described

Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

For Research Use Only. Not for use in diagnostic or therapeutic procedures.