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Purified Mouse Anti-LAR
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BD Transduction Laboratories™
Leukocyte common Antigen-Related
Human (QC Testing), Mouse, Rat (Tested in Development)
Mouse IgG2a
Human LAR aa. 24-196
Western blot (Routinely Tested), Immunofluorescence, Immunohistochemistry, Immunoprecipitation (Not Recommended)
150 kDa
250 µg/ml
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Product Notices

  1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
  2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
  3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
  4. Please refer to for technical protocols.
610350 Rev. 4
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The Leukocyte common Antigen-Related (LAR) receptor protein tyrosine phosphatase (RPTP) is one of approximately 20 known, distinct transmembrane RPTPs.  LAR consists of an extracellular region with three Ig-like and eight fibronectin type III-like (FNIII) domains and a cytoplasmic region containing two tyrosine phosphatase domains typical of RPTPs.  The Ig and FNIII domains of LAR show some sequence similarity to domains in the neural cell adhesion molecule N-CAM, a neural surface glycoprotein which mediates cell adhesion and neurite outgrowth.  Studies suggest that LAR regulates neurite outgrowth and pathfinding during neural development.  N-CAM and other cell adhesion molecules that affect neurite outgrowth, such as L1, TAG-1, and fasciculin II, lack intrinsic kinase or phosphatase activity.  Thus, LAR is part of a distinct class of proteins with both cell adhesion and tyrosine phosphatase functions.  LAR transcripts are alternatively spliced and that splicing is regulated during development.  It is postulated that the various spliced forms of LAR each have specialized functions in the nervous system and play a role in neural development and regeneration.

610350 Rev. 4
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Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
610350 Rev.4
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Development References (3)

  1. Arnott CH, Sale EM, Miller J, Sale GJ. Use of an antisense strategy to dissect the signaling role of protein-tyrosine phosphatase alpha. J Biol Chem. 1999; 274(37):26105-26112. (Biology: Western blot). View Reference
  2. Longo FM, Martignetti JA, Le Beau JM. Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression. J Biol Chem. 1993; 268(35):26503-26511. (Biology). View Reference
  3. Tao J, Malbon CC, Wang HY. Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B. J Biol Chem. 2001; 276(43):39705-39712. (Biology: Western blot). View Reference
610350 Rev. 4

Please refer to Support Documents for Quality Certificates

Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described

Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

For Research Use Only. Not for use in diagnostic or therapeutic procedures.