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Purified Mouse Anti-Neurogenin 3
製品詳細
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BD Transduction Laboratories™
Rat (QC Testing), Human, Mouse (Tested in Development)
Mouse IgG1
Mouse Neurogenin 3 aa. 9-148
Western blot (Routinely Tested), Immunofluorescence (Tested During Development), Immunohistochemistry, Immunoprecipitation (Not Recommended)
23 kDa
250 µg/ml
AB_398111
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
RUO


製品通知

  1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
  2. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
  3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
  4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
610790 Rev. 1
抗体の詳細
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7/Neurogenin 3

Neurogenins are a family of atonal-related bHLH (basic helix-loop-helix) proteins that have been implicated in vertebrate neurogenesis. Members of this family include Neurogenin 1, 2, and 3. In a search for proteins that control early neuronal development, Neurogenin 1 was identified as a novel, Neuro-D-related bHLH protein that is expressed prior to Neuro-D in mouse and Xenopus. Identification of Neurogenins 2 and 3 defined the Neurogenin family. Analysis indicates that neurogenin gene expression defines progenitor populations in the developing nervous system and that neurogenin proteins and Neuro-D function in a cascade. Neurogenin proteins are expressed prior to Neuro-D and subsequent to another bHLH protein, MASH7. Neurogenin 3 is a 244 amino acid, 23 kDa protein that is expressed in fetal, neonatal, and neural tissues, as well as in several neuronal cell lines. Temporal and spatial expression of the neurogenin proteins is critical to proper neural determination and differentiation.

This antibody is routinely tested by western blot analysis.  Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

610790 Rev. 1
フォーマットの詳細
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Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
Purified
610790 Rev.1
引用&参考文献
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開発者向け参考資料 (4)

  1. Cau E, Gradwohl G, Fode C, Guillemot F. Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development. 1997; 124(8):1611-1621. (Biology). 参考文献を見る
  2. Ma Q, Kintner C, Anderson DJ. Identification of neurogenin, a vertebrate neuronal determination gene. Cell. 1996; 87(1):43-52. (Biology). 参考文献を見る
  3. Ma Q, Sommer L, Cserjesi P, Anderson DJ. Mash1 and neurogenin1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands. J Neurosci. 1997; 17(10):3644-3652. (Biology). 参考文献を見る
  4. Sommer L, Ma Q, Anderson DJ. neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci. 1996; 8(4):221-241. (Biology). 参考文献を見る
すべて表示する (4) 表示項目を減らす
610790 Rev. 1

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.