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PE Mouse Anti-Human IL-4
Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation And Storage
Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.
The Anti-Hu–IL-4 antibody, clone 3010.211, is derived from the hybridization of Sp2/0 mouse cells with spleen cells from BALB/c mice immunized with recombinant human IL-4. The Anti-Human Interleukin-4 (Anti-Hu–IL-4) antibody recognizes a 15- to 19-kilodalton (kDa) glycoprotein.
Development References (22)
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Bradding P, Feather IH, Howarth PH, et al. Interleukin 4 is localized to and released by human mast cells. J Exp Med. 1992; 176:1381-1386. (Biology).
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Clerici M, Hakim FT, Venzon DJ, et al. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J Clin Invest. 1993; 91:759-765. (Biology).
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Clerici M, Shearer GM. A TH1 → TH2 switch is a critical step in the etiology of HIV infection. Today. 1993; 14:107-110. (Biology).
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Clinical and Laboratory Standards Institute. 2005. (Biology).
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ElGhazali GEB, Paulie S, Andersson G, et al. Number of interleukin-4– and interferon- γ –secreting human T cells reactive with tetanus toxoid and the mycobacterial antigen PPD or phytohemagglutindistinct response profiles depending on the type of antigen used for activation. Eur J Immunol. 1993; 23:2740-2745. (Biology).
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Elliott MJ, Gamble JR, Park LS, Vadas MA, Lopez AF. Inhibition of human monocyte adhesion by interleukin-4. Blood. 1991; 77:2739-2745. (Biology).
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Elson LH, Nutman TB, Metcalfe DD, Prussin C. Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+ CD27- lymphocyte subpopulation. J Immunol. 1995; 154:4294-4301. (Biology).
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Graziosi C, Pantaleo G, Gantt KR, et al. Lack of evidence for the dichotomy of T H 1 and T H 2 predominance in HIV-infected individuals. Science. 1994; 265:248-252. (Biology).
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Hyjek E, Lischner HW, Hyslop T, et al. Cytokine patterns during progression to AIDS in children with perinatal HIV infection. J Immunol. 1995; 155:4060-4071. (Biology).
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Idzerda RL, March CJ, Mosley B, et al. Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med. 1990; 171(3):861-873. (Biology). View Reference
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Keegan AD, Nelms K, Wang L-M, Pierce JH, Paul WE. Interleukin 4 receptor: signaling mechanisms. Immunol Today. 1994; 15:423-432. (Biology).
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Maggi E, Mazzetti M, Ravina A, et al. Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH 0 cells. Science. 1994; 265:244-248. (Biology).
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Nagler A, Lanier LL, Phillips JH. The effects of IL-4 on human natural killer cells: A potent regulator of IL-2 activation and proliferation. J Immunol. 1988; 141:2349-2351. (Biology).
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Openshaw P, Murphy EE, Hosken NA, et al. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med. 1995; 182(5):1357-1367. (Biology). View Reference
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Paul WE. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood. 1991; 77(9):1859-1870. (Biology). View Reference
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Picker LJ, Singh MK, Zdraveski Z, et al. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood. 1995; 86:1408-1419. (Biology).
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Powrie F, Coffman RL. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol Today. 1993; 14:270-274. (Biology).
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Romagnani S, Del Prete G, Maggi E, et al. Human TH1 and TH2 subsets. Int Arch Allergy Immunol. 1992; 99:242-245. (Biology).
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Street NE, Mosmann TR. Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J. 1991; 5:171-176. (Biology).
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Although not required, these products are manufactured in accordance with Good Manufacturing Practices.