The CD26 antibody, clone L272, is derived from hybridization of mouse Sp2/0 cells with spleen cells from BALB/c mice immunized with E1αPGF/JY cells.
CD26 recognizes a 120-kilodalton (kDa) antigen that is identical to the enzyme dipeptidyl peptidase (DPP), a serine protease. It is associated with the binding of the TAT transactivating protein of the human immunodeficiency virus (HIV). CD26 and CD45 act in a co-stimulatory fashion on T lymphocytes.
Development References (9)
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Blazquez M, Maduceno J, Gonzalez R, et al. Selective decrease of CD26 expression in T cells from HIV-1 infected individuals. J Immunol. 1992; 149(9):3073-3077. (Biology).
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Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
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Clinical and Laboratory Standards Institute. 2005. (Biology).
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Duke-Cohan JS, Morimoto C, Schlossman SF. Targeting of an activated T-cell subset using a bispecific antibody-toxin conjugate directed against CD4 and CD26. Blood. 1993; 82:2224-2234. (Biology).
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Gutheil WG, Subramanyam M, Flentke GR, et al. Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity.. Proc Natl Acad Sci USA. 1994; 91(14):6594-8. (Biology). View Reference
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Morimoto C, Kameoka J, Tanaka T, Schlossman SF. Schlossman SF, Boumsell L, Gilks W, et al, ed. Leucocyte Typing V: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1995:1105-1114.
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Muñoz E, Blazquez MV, Madueño JA, Rubio G, Peña J. CD26 induces T-cell proliferation by tyrosine protein phosphorylation.. Immunology. 1992; 77(1):43-50. (Biology). View Reference
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Stein H, Schwarting R, Niedobitek G. Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:412-415.
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Vanham G, Kestens L, De Meester I, et al. Decreased expression of the memory marker CD26 on both CD4+ and CD8+ T lymphocytes of HIV-infected subjects.. J Acquir Immune Defic Syndr. 1993; 6(7):749-57. (Biology). View Reference
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