BD Horizon™ BV421 Mouse Anti-Human CD179b (λ5)
Clone HSL11.rMAb (RUO)
Preparation And Storage
Recommended Assay Procedures
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Product Notices
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- An isotype control should be used at the same concentration as the antibody of interest.
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Companion Products
The HSL11.rMAb monoclonal antibody specifically recognizes CD179b, which is also known as Ig Lambda 5, λ5 or Ig omega. CD179b is a ~23 kDa protein within the immunoglobulin gene superfamily and is a component of the pre-B cell receptor complex (pre-BCR). The pre-BCR is a heterodimer comprised of an immunoglobulin heavy chain (IgH) and a surrogate light (SL) chain, which is composed of non-covalently linked CD179b (λ5) and CD179a (VpreB) proteins. The pre-BCR is expressed during the early stages of B lymphocytes development and its expression is restricted to pre-B cell stage of B cell development, whereas the expression of SL chain is restricted to both pro-B and pre-B cell stages of B cell development. Due to restricted lineage expression, CD179b (λ5) along with CD179a (VpreB) may serve as a useful marker of precursor B cells and can be utilized for immunophenotyping precursor B cell lymphoblastic lymphomas. The pre-BCR plays a role in signal transduction for cell proliferation and differentiation from the proB cell to the preB cell stage, allelic exclusion of IgH chain loci, and Ig light chain gene rearrangements. CD179b (λ5) is required for precursor B cell development and its deficiency could prevent the maturation and survival of the B cell precursors beyond the pre-B cell stage and can lead to B cell deficiency and agammaglobulinemia.
Development References (4)
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Karasuyama H, Lebien TW, Copper MD, Clark EC. CD179 Workshop report. In: Mason D. David Mason .. et al., ed. Leucocyte typing VII : white cell differentiation antigens : proceedings of the Seventh International Workshop and Conference held in Harrogate, United Kingdom. Oxford: Oxford University Press; 2002:112-115.
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Kiyokawa N, Sekino T, Matsui T, et al. Diagnostic importance of CD179a/b as markers of precursor B-cell lymphoblastic lymphoma.. Mod Pathol. 2004; 17(4):423-9. (Clone-specific). View Reference
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Tsuganezawa K, Kiyokawa N, Matsuo Y, et al. Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human pre-B-cell receptor.. Blood. 1998; 92(11):4317-24. (Immunogen). View Reference
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Winkler TH, Mårtensson IL. The Role of the Pre-B Cell Receptor in B Cell Development, Repertoire Selection, and Tolerance. Front Immunol. 2018; 15(9):2423. (Biology). View Reference
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