CD38 polyclonal antibody, also known as ADP-ribosyl cyclase, is a type II transmembrane glycoprotein able to transform NADP+ into cyclic ADP-ribose, NAADP+ and ADP-ribose. CD38 is expressed at variable levels on the majority of hematopoietic cells (during early differentiation and activation) and in some non-hematopoietic tissues. It is expressed at high levels on plasma cells (CD38+++) and, due to its strong reactivity, CD38 is considered a "specific plasma cell marker"; but it is also present on thymocytes, activated T cells, NKs monocytes, and basophils. CD38 has been reported to play a role as regulator (positive and negative) of cell activation and proliferation, and to be involved in adhesion between lymphocytes and endothelial cells. The multi-epitope anti-human CD38 is a monoclonal antibody designed to be used as a direct immunofluorescence reagent in order to identify cells that express the CD38 antigen by flow cytometry.
The simultaneous assessment of the expression of CD38 and CD138 represents the best combination of markers for the identification of plasma cells.
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