CD7 is a 40KDa glycoprotein expressed on thymocytes, mature T cells, natural killer cells, pluripotent hematopoietic stem
cells, and progenitors of lymphoid and myeloid cells. CD7 is one of the earliest T-cell-specific antigens to be expressed in
lymphocytes, and the only early marker to persist throughout differentiation. Analysis of the expression of the CD7 antigen
as a T cell line marker, in combination with those CD3 and CD5 antigens, is useful in the diagnosis of T cell proliferative
syndromes such as T-ALL and T-prolymphocyte T cell leukaemias. The absence of expression of CD7, or its abnormal
expression, can provide useful information in the case of Sezary's syndrome or chronic lymphoid leukaemia. The CD7
antigen can be expressed by certain acute immature myeloid leukaemias.
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For In Vitro Diagnostic Use.
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