The TÜ145 monoclonal antibody specifically binds to CD48. CD48 belongs to the CD2 family within the immunoglobulin superfamily. CD48 is a ~43 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD48 is strongly expressed on lymphocytes, monocytes and macrophages and weakly on granulocytes. The expression of CD48 is upregulated following lymphocyte activation and by Epstein-Barr virus (EBV) infection. CD48 binds with high affinity to CD244 and with low affinity to CD2. These receptor-ligand interactions can augment or inhibit leukocyte responses.
This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.