U87
U87
Preparation And Storage
Product Notices
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Receptor-like protein tyrosine phosphatases (RPTPs) represent an important pathway for signal transduction via modification of protein tyrosine phosphorylation status. RPTPα is widely expressed and is particularly abundant in brain. Structurally, it is typical of RPTPs in that it has an intracellular region containing two tandem catalytic domains linked to a transmembrane and an extracellular region. However, unlike many RPTPs, the extracellular region of RPTPα is small (123 residues) and lacks any obvious structural motifs, though the protein is known to be heavily glycosylated. Both catalytic domains of RPTPα have intrinsic in vitro activity, but their exact roles in vivo remain uncertain. It has been postulated that due to their transmembrane nature, RPTPs are initiators for a cascade of intracellular signaling events, much like receptor tyrosine kinases.
Development References (3)
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Sap J, D'Eustachio P, Givol D, Schlessinger J. Cloning and expression of a widely expressed receptor tyrosine phosphatase. Proc Natl Acad Sci U S A. 1990; 87(16):6112-6116. (Biology). View Reference
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Zheng XM, Pallen CJ. Expression of receptor-like protein tyrosine phosphatase alpha in rat embryo fibroblasts activates mitogen-activated protein kinase and c-Jun. J Biol Chem. 1994; 269(37):23302-23309. (Biology). View Reference
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Zheng XM, Wang Y, Pallen CJ. Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature. 1992; 359(6393):336-339. (Biology). View Reference
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
