The SN2 monoclonal antibody specifically recognizes a 37-42 kDa membrane glycoprotein expressed on a subset of peripheral lymphocytes, monocytes, immature thymocytes and on most platelets. CD165, also known as gp37 or AD2, is expressed at low levels on most thymocytes and thymic epithelial cells. CD165 has been detected on islet cells of the pancreas, Bowman's capsule of the kidney and on central nervous system neurons. SN2 antigen has been reported to be identical, or very similar, to the T-cell acute lymphoblastic leukemia antigen, TALLA-1. CD165 has been reported to play a role in the adhesion between thymocytes and thymic epithelial cells during development.
The antibody was conjugated to BD Horizon Red 718, which has been developed exclusively for BD Biosciences as a better alternative to Alexa Fluor® 700. BD Horizon Red 718 can be excited by the red laser (628 – 640 nm) and, with an Em Max around 718 nm, it can be detected using a 730/45 nm filter. Due to similar excitation and emission properties, we do not recommend using R718 in combination with APC-R700 or Alexa Fluor® 700.