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Anti-Human COX-1 FITC/COX-2 PE
Product Details
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BD™
Human
Flow cytometry
RUO (GMP)
Phosphate buffered saline with BSA, beta-lactoglobulin, and 0.1% sodium azide.


Description

Anti–COX-1, clone AS70, is an antibody raised against human recombinant COX-1 protein. The antibody does not cross-react with human recombinant COX-2 by ELISA.

Anti–COX-2, clone AS67, is an antibody raised against human recombinant COX-2 protein. The antibody does not cross-react with human recombinant COX-1 by ELISA.

Anti–COX-1 recognizes a homodimeric, heme-containing, glycosylated, constitutively expressed enzyme that is located on the lumenal surface of the endoplasmic reticulum and on the inner and outer membranes of the nuclear envelope. Anti–COX-2 recognizes the inducible form of this enzyme.


Anti–COX-1, clone AS70, is an antibody raised against human recombinant COX-1 protein. The antibody does not cross-react with human recombinant COX-2 by ELISA.

Anti–COX-2, clone AS67, is an antibody raised against human recombinant COX-2 protein. The antibody does not cross-react with human recombinant COX-1 by ELISA.

Anti–COX-1 recognizes a homodimeric, heme-containing, glycosylated, constitutively expressed enzyme that is located on the lumenal surface of the endoplasmic reticulum and on the inner and outer membranes of the nuclear envelope. Anti–COX-2 recognizes the inducible form of this enzyme.

Preparation And Storage

Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.

334090 Rev. 1
Components
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Description Clone Isotype
Anti-COX-1 FITC N/A N/A
PE Mouse Anti-Human COX-2 AS67 IgG1, κ
334090 Rev. 1
Citations & References
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Development References (9)

  1. Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
  2. Clinical and Laboratory Standards Institute. 2005. (Biology).
  3. Fletcher BS, Kujubu DA, Perrin DM, Herschman HR. Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. J Biol Chem. 1992; 267:4338-4344. (Biology).
  4. Herschman HR. Prostaglandin synthase 2. Biochim Biophys Acta. 1996; 1299:125-140. (Biology).
  5. Kang RY, Freire-Moar J, Sigal E, Chu C-Q. Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis. Br J Rheumatology. 1996; 35:711-718. (Biology).
  6. Maloney CG; Kutchera WA; Albertine KH; McIntyre TM; Prescott SM; Zimmerman GA. Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils. J Immunol. 1998; 160(3):1402-1410. (Biology). View Reference
  7. Ruitenberg JJ; Waters CA. A rapid flow cytometric method for the detection of intracellular cyclooxygenases in human whole blood monocytes and a COX-2 inducible human cell line. J Immunol Methods. 2003; 274(1-2):93-104. (Biology). View Reference
  8. Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem. 1996; 271:33157-33160. (Biology).
  9. Spencer AG, Woods JW, Arakawa T, Singer II, Smith WL. Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy. J Biol Chem. 1998; 273:9886-9893. (Biology).
View All (9) View Less
334090 Rev. 1

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For Research Use Only. Not for use in diagnostic or therapeutic procedures. 

 

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