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BD FastImmune™ Anti-Human CD2/CD2R Purified
(RUO (GMP))Anti-Human CD2/CD2R Purified
Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Description
CD2, clone L303.1, and CD2R, clone L304.1, are each derived by the fusion of SP2/0 myeloma cells with splenocytes from BALB/c mice immunized with CD3-activated human T lymphocytes. The CD2 molecule is an Mr 50-kilodalton (kd) human lymphocyte antigen. At least three different functional epitopes of CD2 have been defined. One epitope (recognized by Leu™-5b) is the sheep red blood cell (SRBC) receptor. The other two epitopes, CD2 and CD2R, are binding sites for monoclonal antibodies that, when used together, deliver signals for polyclonal T-lymphocyte activation.
Preparation And Storage
The monoclonal antibody is supplied as 125 μg each of CD2 and CD2R in 250 μL of phosphate-buffered saline (PBS) containing 0.01% sodium azide. The vial should be stored at 2° to 8°C. Each reagent is stable for the period shown on the bottle label when stored as directed.
Description | Clone | Isotype | EntrezGene ID |
---|---|---|---|
CD2 Purified | L303.1 | IgG2a, κ | 3689 |
CD2R Purified | L304.1 | IgG1, κ | 914 |
Development References (6)
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Huet S, Wakasugi H, Sterkers G, et al. T cell activation via CD2 (T, gp50): The role of accessory cells in activating resting T cells via CD2. J Immunol. 1986; 137:1420-1428. (Biology).
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Lanier LL, Phillips JH, Hackett J Jr, Tutt M, Kumar V. Natural killer cells: definition of a cell type rather than a function. J Immunol. 1986; 137(9):2735-2739. (Biology). View Reference
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Maino VC, Suni MA, Ruitenberg JJ. Rapid flow cytometric method for measuring lymphocyte subset activation.. Cytometry. 1995; 20(2):127-33. (Biology). View Reference
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Meuer SC, Hussey RE, Fabbi M, et al. An alternative pathway of T cell activation: A functional role for the 50 kD T11 sheep erythrocyte receptor protein. Cell. 1984; 36:897. (Biology).
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Meuer SC. Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:270-272.
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Parish CR, McPhun V, Warren HS. Is a natural ligand of the T lymphocyte CD2 molecule a sulfated carbohydrate?. J Immunol. 1988; 3498-3504. (Biology).
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Although not required, these products are manufactured in accordance with Good Manufacturing Practices.