The CD81 antibody, clone JS-81, is derived from hybridization of P3/NS1/1-Ag4-1 mouse myeloma cells with spleen cells isolated from mice immunized with the Burkitt lymphoma cell line, Ramos.
The CD81 antibody recognizes a 26-kilodalton (kDa) member of the tetraspanin family (TM4SF). The CD81 antigen is also known as TAPA-1.
Development References (12)
-
Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J Immunol. 1992; 149(9):2841-2850. (Biology). View Reference
-
Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
-
Clinical and Laboratory Standards Institute. 2005. (Biology).
-
Fearon DT, Carroll MC. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu Rev Immunol. 2000; 18:393-422. (Biology).
-
Flint M, Maidens C, Loomis-Price LD, et al. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. J Virol. 1999; 73:6235-6244. (Biology).
-
Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol. 1998; 16:89-109. (Biology). View Reference
-
Oren R, Takahashi S, Doss C, Levy R, Levy S. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol Cell Biol. 1990; 10(8):4007-4015. (Biology). View Reference
-
Pesando JM, Hoffman P, Conrad T. Malignant human B cells express two populations of p24 surface antigens. J Immunol. 1986; 136:2709-2714. (Biology).
-
Petracca R, Falugi F, Galli G, et al. Structure-function analysis of hepatitis C virus envelope-CD81 binding. J Virol. 2000; 74:4824-4830. (Biology).
-
Takahashi S, Doss C, Levy S, Levy R. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. J Immunol. 1990; 145:2207-2213. (Biology).
-
Tedder TF, Wagner N, Engel P. Schlossman SF, Boumsell L, Gilks W, et al, ed. Leukocyte Typing V. White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1995:684-688.
-
van Zelm MC, Smet J, Adams B, et al. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest. 2010; 120:1265-1274. (Biology).
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