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CD138-APC-C750™
Product Details
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BD Cytognos™
SDC1; Syndecan 1; Syndecan-1
Human
Mouse BALB/c IgG1
Human U266 Myeloma Cell Line
3 µl/test
6382
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IVD


cyt-138ac750 Rev. 1
Antibody Details
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B-A38

The B-A38 monoclonal antibody specifically recognizes an extracellular epitope on human CD138 that is also known as Syndecan-1 (SDC-1). CD138 is a transmembrane type I and surface heparan sulfate proteoglycan that is expressed as an ~65-70 kDa core protein dimer with variable glycosylation. CD138 is encoded by SDC1 (syndecan 1) which belongs to the syndecan proteoglycan family. CD138 is expressed on pre-B cells, immature B cells, and plasma cells, but not on mature circulating B-lymphocytes, as well as by embryonic mesenchymal cells and certain epithelial and endothelial cells. It is strongly expressed on multiple-myeloma-derived cell lines and malignant plasma cell populations. CD138 is involved in many cellular functions including cell-cell and cell matrix adhesion. It binds to multiple extracellular matrix (ECM) proteins and soluble bioactive factors through its heparan sulfate side chains. ECM protein ligands for CD138 include fibronectin, certain collagens, tenascin, thrombospondin, and antithrombin III. Certain cytokines and growth factors are bound by CD138 and accumulated on CD138-positive cells which contributes to the sensitive recognition and response to these factors by neighboring cells. These may include fibroblast, hepatocyte, and epidermal growth factors and April. A soluble shed form of CD138 has also been described which can affect the stability and function of CD138.

cyt-138ac750 Rev. 1
Format Details
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APC-C750
APC-C750 is part of the BD red family of dyes. This fluorochrome has an excitation maximum (Ex Max) at 651-nm and an emission maximum (Em Max) at 779-nm. APC-C750 is designed to be excited by the Red laser (633, 635 nm) . Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
APC-C750
Red 633 nm, 635 nm
651 nm
779 nm
cyt-138ac750 Rev.1
Citations & References
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cyt-138ac750 Rev. 1

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For In Vitro Diagnostics Use.

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