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FITC Mouse Anti-Human CD26
Product Details
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BD™
DPP IV; DPPIV; DPP4; Dipeptidyl peptidase IV; ADABP; ADCP-2; TP103
Human
Mouse BALB/c IgG2a, κ
E1αPGF/JY cells
Flow cytometry
20 μL
1803
Phosphate buffered saline with gelatin and 0.1% sodium azide.
RUO (GMP)


Preparation And Storage

The FITC and PE conjugates are each supplied in 1.0 mL of phosphate buffered saline containing gelatin and 0.1% sodium azide. Each lot is bottled at titer as determined by immunofluorescence staining of lymphocytes in peripheral blood. Please refer to the vial label for antibody concentration. The vial should be stored at 2° to 8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.

340426 Rev. 1
Antibody Details
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L272

The CD26 antibody, clone L272, is derived from hybridization of mouse Sp2/0 cells with spleen cells from BALB/c mice immunized with E1αPGF/JY cells.

CD26 recognizes a 120-kilodalton (kDa) antigen that is identical to the enzyme dipeptidyl peptidase (DPP), a serine protease. It is associated with the binding of the TAT transactivating protein of the human immunodeficiency virus (HIV). CD26 and CD45 act in a co-stimulatory fashion on T lymphocytes.

340426 Rev. 1
Format Details
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FITC
Fluorescein (FITC) is part of the BD blue family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 494-nm and an emission maximum (Em Max) at 518-nm. FITC is designed to be excited by the Blue laser (488-nm) and detected using an optical filter centered near 520 nm (e.g., a 530/30-nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
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FITC
Blue 488 nm
494 nm
518 nm
340426 Rev.1
Citations & References
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Development References (9)

  1. Blazquez M, Maduceno J, Gonzalez R, et al. Selective decrease of CD26 expression in T cells from HIV-1 infected individuals. J Immunol. 1992; 149(9):3073-3077. (Biology).
  2. Duke-Cohan JS, Morimoto C, Schlossman SF. Targeting of an activated T-cell subset using a bispecific antibody-toxin conjugate directed against CD4 and CD26. Blood. 1993; 82:2224-2234. (Biology).
  3. Gutheil WG, Subramanyam M, Flentke GR, et al. Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity.. Proc Natl Acad Sci USA. 1994; 91(14):6594-8. (Biology). View Reference
  4. Morimoto C, Kameoka J, Tanaka T, Schlossman S. Overview of CD26. In: Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995:1105-1114.
  5. Muñoz E, Blazquez MV, Madueño JA, Rubio G, Peña J. CD26 induces T-cell proliferation by tyrosine protein phosphorylation.. Immunology. 1992; 77(1):43-50. (Biology). View Reference
  6. Plana M, Font J, Viñas O, Martorell J, Ingelmo M, Vives J. Responsiveness of T lymphocytes from systemic lupus erythematosus to signals provided through CD26 antigen.. Clin Immunol Immunopathol. 1994; 72(2):227-32. (Biology). View Reference
  7. Stein H, Schwarting R, Niedobitek G. Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:412-415.
  8. Ulmer AJ, Mattern T, Flad HD. Expression of CD26 (dipeptidyl peptidase IV) on memory and naive T lymphocytes.. Scand J Immunol. 1992; 35(5):551-9. (Biology). View Reference
  9. Vanham G, Kestens L, De Meester I, et al. Decreased expression of the memory marker CD26 on both CD4+ and CD8+ T lymphocytes of HIV-infected subjects.. J Acquir Immune Defic Syndr. 1993; 6(7):749-57. (Biology). View Reference
View All (9) View Less
340426 Rev. 1

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