The Most Cited Personal Flow Cytometer
The unique ability to rapidly analyze multiple cellular properties at the single-cell level has made flow cytometry an essential tool, from immunology and cell biology to cancer research, aquatic research, bioprocessing, biofuels development, and synthetic biology.
Easy to use, reliable, transportable and affordable, the BD Accuri™ C6 Plus personal flow cytometer brings cell analysis within reach for new applications and new flow cytometry users.
With more than 7,500 citations*, BD Accuri™ systems are the most cited personal flow cytometers. Across the globe, in the lab and in the field, they provide essential data for both routine and exploratory studies in fast advancing scientific fields such as immuno-oncology, CRISPR gene editing, precision medicine, small particle analysis, and nanotechnology.
A Sampling of Customers and Applications
“Since there’s only so much blood that we can take from the astronaut in space, we have to be really efficient with what we can do. For each antibody stain, we’re using 50 μL of whole blood, and that’s more than enough. Because the BD Accuri C6 collects many events from just 50 μL of blood, we can do detailed phenotyping with very limited blood volumes.”
—Richard Simpson, immunologist, University of Houston, TX
Application: Effects of space flight on human immune systems
“I wish I had started on that machine! The software is very user friendly. Everything is on that first page. When you’re collecting your samples, it’s easy to follow, easy to find the next step of what to do. I’m also surprised at how such a small machine can provide such consistently nice data. The resolution is great.”
—Karina Palomares, stem cell researcher, University of California San Diego, CA
Application: Differentiation of cardiomyocytes from human embryonic stem cells
“It's a combination of the price, which makes it purchasable by a single lab, and the size, that can change how you go about designing your experiments and the number of experiments you can perform. If you have to sign up a week in advance for a shared core facility, it limits the experiments you can do.”
—David Ferguson, pathologist and molecular biologist, University of Michigan, Ann Arbor, MI
Application: Mechanisms of DNA repair and its role in cancer, immunity, and development
“[Flow cytometry is] an absolutely essential way to accurately measure proliferation of the cell populations you’re working with, and to determine if cells proliferate or die upon a genetic or chemical perturbation. For tumor biologists who study cancer cells in culture, this is an essential method to have in your toolbox.”
—Emmy Verschuren, cancer researcher, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland
Application: Cancer model systems
“Having the BD Accuri C6 in the lab has moved things along quickly. Multiple people use it multiple times a day. Our core flow cytometer facility is on a different campus about a 10-minute drive away. Had we had to use the core facility, the pace of our research would have slowed to a halt.… For my lab and me, it means affordability without sacrificing capabilities.”
—Chase Beisel, chemical engineer, North Carolina State University, Raleigh, NC
Application: CRISPR-Cas microbial engineering
“One of the machine's acquisition options enables volumetric measurements. This means that we can obtain absolute counts within a set volume of sample, which is essential for accurate quantification. The four fluorescence detectors with optical filters enable simultaneous analysis of different bacterial groups through the use of different microbial probes.”
—Gemma Walton and Sandra Tejero, microbiologists, University of Reading, UK
Application: Characterization of gut microbiota using Flow-FISH
“I was very happy with [the BD Accuri C6]. The main constraint on Tara is that it’s a small sailboat, not a big ship. We did not have a lot of bench space, so the dimensions were really important for us. I also found it to be very stable. A ship is not a lab, and the boat is moving all the time. We calibrated it every day for six months, both for fluorescence and size. It was nice to see how, through all the abuse and waves and ice, the measurements remained stable over time."
—Lee Karp-Boss, marine researcher, University of Maine, Orono, ME
Application: Characterization of planktonic ecosystems, Tara Expeditions
You'll find more customer stories on our BD Accuri™ News
A Sampling of Recent Citations
Friedland AE, Baral R, Singhai P, et al. Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications. Genome Biol. 2015;16: 1–10. PubMed
Platt RJ, Chen S, Zhou Y, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 2014;159:440–455. PubMed
Stephen HM, Khoury RJ, Majmudar PR, et al. Epigenetic suppression of neprilysin regulates breast cancer invasion. Oncogenesis. 2016 Mar 7;5:e207. PubMed
Bigley AB, Rezvani K, Shah N, et al. Latent CMV infection enhances anti‐tumor cytotoxicity through accumulation of NKG2C+ NK-cells in healthy humans. Clin. Exp Immunol. 2016. [Epub ahead of print] PubMed
Safi R, Nelson ER, Chitneni SK, et al. Copper signaling axis as a target for prostate cancer therapeutics. Cancer Res. 2014;74(20):5819–5831. PubMed
Cao FY, Feng JX, Long Y, Zeng X, Zhang XZ. "A smart fluorescence nanoprobe for the detection of cellular alkaline phosphatase activity and early osteogenic differentiation. Nanomedicine. 2016. [Epub ahead of print] PubMed
Yan T, Wang H, Zhao M, et al. Glycyrrhizin protects against acetaminophen-induced acute liver injury via alleviating tumor necrosis factor α-mediated apoptosis. Drug Metab Dispos. 2016;44(5): 720-731. PubMed
Dalal C, Saha A, Jana NR. Nanoparticle Multivalency Directed Shifting of Cellular Uptake Mechanism. J. Phys. Chem. 2016;120(12):6778-6786. ACS
Geng H, Sale KL, Tran-Gyamfi MB, Lane TW, Yu ET. Longitudinal Analysis of Microbiota in Microalga Nannochloropsis salina Cultures. Microbial Eco. 2016. [Epub ahead of print] PubMed
Wu B, Capilato J, Pham MP, et al. Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition. FASEB. 2016: fj-201500029R. [Epub ahead of print] PubMed
* Results of searches on “Accuri C6” at Google Scholar in March, 2017 showed >7,500 citations (excluding patents).