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APC-H7 Mouse Anti-Human CD81
Product Details
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TAPA1; Tetraspanin-28; Tspan-28; TSPAN28; CVID6; S5.7; M38
Mouse IgG1, κ
Flow cytometry
100 µg/mL
5 μL
V B070

656647 Rev. 1
Antibody Details
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The CD81 antibody, clone JS-81, is derived from hybridization of P3/NS1/1-Ag4-1 mouse myeloma cells with spleen cells isolated from mice immunized with the Burkitt lymphoma cell line, Ramos.

The CD81 antibody recognizes a 26-kilodalton (kDa) member of the tetraspanin family (TM4SF). The CD81 antigen is also known as TAPA-1.

656647 Rev. 1
Format Details
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The BD Horizon™ APC-H7 dye is a part of the BD APC red family of dyes. This tandem fluorochrome is comprised of a Allophycocyanin (APC) donor that has excitation maxima (Ex Max) of 659 nm and an acceptor dye, H7, with an emission maximum (Em Max) at 782 nm. APC-H7, driven by BD innovation, is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 780 nm (e.g., a 760/60 nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
Red 627-640 nm
659 nm
782 nm
656647 Rev.1
Citations & References
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Development References (12)

  1. Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J Immunol. 1992; 149(9):2841-2850. (Biology). View Reference
  2. Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
  3. Clinical and Laboratory Standards Institute. 2005. (Biology).
  4. Fearon DT, Carroll MC. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu Rev Immunol. 2000; 18:393-422. (Biology).
  5. Flint M, Maidens C, Loomis-Price LD, et al. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. J Virol. 1999; 73:6235-6244. (Biology).
  6. Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol. 1998; 16:89-109. (Biology). View Reference
  7. Oren R, Takahashi S, Doss C, Levy R, Levy S. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol Cell Biol. 1990; 10(8):4007-4015. (Biology). View Reference
  8. Pesando JM, Hoffman P, Conrad T. Malignant human B cells express two populations of p24 surface antigens. J Immunol. 1986; 136:2709-2714. (Biology).
  9. Petracca R, Falugi F, Galli G, et al. Structure-function analysis of hepatitis C virus envelope-CD81 binding. J Virol. 2000; 74:4824-4830. (Biology).
  10. Takahashi S, Doss C, Levy S, Levy R. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. J Immunol. 1990; 145:2207-2213. (Biology).
  11. Tedder TF, Wagner N, Engel P. Schlossman SF, Boumsell L, Gilks W, et al, ed. Leukocyte Typing V. White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1995:684-688.
  12. van Zelm MC, Smet J, Adams B, et al. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest. 2010; 120:1265-1274. (Biology).
View All (12) View Less
656647 Rev. 1

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