藥物動力學/毒性研究

滲透性及轉運載體蛋白的研究

轉運載體蛋白在藥物及其代謝產物的運輸及排泄方面都起著至關重要的作用。抑制膜轉運蛋白的藥物能夠改變共同作用藥物的吸收、分佈以及排泄,這些共同作用的藥物是這些轉運載體蛋白的受質,並且能夠影響生物利用度或者藥物之間的相互作用。

BD GentestSM合約研發服務提供一系列服務,借由體外模型,表達ABCSLC亞族的人源和動物源的轉運體,用於藥物轉運作用的評估。


瞭解更多關於藥物發展服務

ABC Transporter Services
P-gp/MRP/BCRP/BSEP membranes and vesicles studies, as well as MDR1 LLC-PK1 and Caco-2 Cell Model studies.

Enzyme Inhibition Studies
Most drug-drug interactions are metabolism based and tied to the cytochrome P450 family of enzymes, although other enzymes may be involved including UGTs and transporters.

Enzyme Induction Studies
In vitro models using human hepatocytes can predict the potential of drug candidates to be enzyme inducers. Induction in preclinical species can shed light on the results of animal pharmacokinetic studies and may be predictive of tumorigenicity.


FDA 指導準則文件檔

BD 生物科學提供了最先進的滲透測試方法,並符合美國FDA指導準則檔要求

FDA-sponsored guidance documents.


To inquire about BD GentestSM Contract Research Services, locate your nearest BD Biosciences office.