ADME Resources

Drug Permeability

• Automation of Pre-coated PAMPA Plates Improves Predictability, Reproducibility, and Efficiency
• A Novel Design of Artificial Membrane for Improving the PAMPA Model
• Use of Automation-Compatible 24-Well Insert System for Various Cell-Based Assays
• Comparison of the BD BioCoat™ Intestinal Epithelial Environment with the Conventional 21-Day Caco-2 System
• Use of the 3-Day BD BioCoat HTS Caco-2 Assay System for Compound Permeability Measurements
• Design and Evaluation of an Automation-Compatible Multiwell™ Insert for Cell-Based Assays

Drug Transport

• Cloning and Characterization of Cynomolgus Monkey and Rhesus Monkey Organic Anion Transporting Polypeptide 1B3, and Comparison of Their Function with Human OATP1B3

Cytochrome P450 Inhibition

• Time-Dependent Inhibition (TDI) of Human Cytochrome P450: Evaluation of Screening Methods Utilizing RapidFire® MS Technology
• Differential Time- and NADPH-dependent inhibition of CYP2C19 by enantiomers of fluoxetine
• Validation of GLP Time-Dependent Cytochrome P450 Inhibition Assays with Assays with LC/MS Detection

• Tissue Fractions Brochure
• Transporter Brochure
• Hepatocyte Brochure
• ADME Discovery Services Brochure

• Cytochrome P450 Inhibition

Drug Permeability

• BD Falcon™ HTS 24-Multiwell™ Insert System
• BD Falcon HTS 96-Multiwell Insert Systems

Metabolism

• BD UltraPool™ HLM 150

Services

• Services: CYP Inhibition Service with RapidFire
• Services: High Throughput Reaction Phenotyping
• Services: Metabolic Stability in Microsomes
• Services: Metabolic Stability in Hepatocytes

Drug Permeability

• Lucifer Yellow Permeability Assay Using BD Falcon HTS 96-Multiwell Insert Systems
• Preparation of 21-Day Caco-2 Cell Monolayers for BD Falcon 96-Multiwell Insert Systems
• Preparation of 21-Day Caco-2 Cell Monolayers for BD Falcon 96-Multiwell Insert Systems

Drug Transport

• Drug Transport Assay for BD Falcon 24-Multiwell Insert Systems

Cytochrome P450 Metabolism

• Enzyme Assays, CYP2C8: Assay Conditions for Paclitaxel 6(alpha)-Hydroxylation
• Enzyme Assays, CYP2C9: Assay Conditions for Diclofenac 4’-Hydroxylation
• Enzyme Assays, CYP2D6: Assay Conditions for Bufuralol 1’-Hydroxylation

Immunoblotting and Immunoinhibition

• Antibody Specificity Tables: Human FMO Immunoblotting Antibodies
• Antibody Specificity Tables: Human P450 Immunoblotting Antibodies
• Antibody Specificity Tables: Human P450 Inhibitory Antibodies
• Antibody Specificity Tables: Human UGT Immunoblotting Antibodies
• Antibody Specificity Tables: Rat P450 Immunoblotting Antibodies

Drug Permeability

• BD Falcon HTS 96-Multiwell Insert Systems

Drug Transport

• Product Use Guidelines for Automated or Manual 24-Multiwell Insert Systems

Metabolism

• Mammalian Liver Cytosol
• Mammalian Liver Microsomes
• Mammalian Liver S9