ADME/Tox Research

Permeability and Transport Studies

Transporters are essential in the delivery and excretory processes of drugs and their metabolites. Drugs that inhibit membrane transporters can alter the absorption, disposition, and elimination of co-administered drugs that are substrates of these transport proteins and can affect bioavailability or cause drug-drug interactions.

BD Gentest^SM Contract Research Services offers a range of services to evaluate drug-transporter interactions using in vitro models expressing human and animal transporters from the ABC and SLC superfamilies.

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Learn more about our Development Services

ABC Transporter Services
P-gp/MRP/BCRP/BSEP membranes and vesicles studies, as well as MDR1 LLC-PK₁ and Caco-2 Cell Model studies.

SLC Transporter Studies
Transportocytes - Xenopus laevis Ooctyes Preinjected with OAT, OATP, OCT, NTCP, and PEPT Transporter cRNA.

Enzyme Inhibition Studies
Most drug-drug interactions are metabolism based and tied to the cytochrome P450 family of enzymes, although other enzymes may be involved including UGTs and transporters.

Enzyme Induction Studies
In vitro models using human hepatocytes can predict the potential of drug candidates to be enzyme inducers. Induction in preclinical species can shed light on the results of animal pharmacokinetic studies and may be predictive of tumorigenicity.

FDA-sponsored guidance documents

BD Biosciences offers several state-of-the-art induction testing methods that adhere to applicable FDA-sponsored guidance documents.

To inquire about BD Gentest^SM Contract Research Services, locate your nearest BD Biosciences office.