ADME/Tox Research
Products
Metabolism Products
Drug metabolism plays a critical role in the toxicity, efficacy or detoxification of a drug compound. Understanding how a drug compounds' enzymatic metabolic pathways and metabolic rates influence its clearance, metabolite concentration, and potential drug-drug interactions is a critical component to developing safe and effective drugs.
BD Biosciences extensive portfolio of products and services to support the characterization of drug metabolism and drug-drug interactions include: recombinant drug metabolizing enzymes, human- and animal-derived hepatocytes and tissue fractions, antibodies, chemical substrates, metabolites and inhibitors needed to perform metabolic studies.
NEW! BD UltraPool HLM 150
The BD UltraPool™ HLM 150 is the first commercially available large donor pool of 150 donors statistically modeled to provide researchers with a high degree of lot-to-lot consistency for CYP and UGT enzyme activity, and to naturally represent the “average patient” and known CYP polymorphisms.
BD UltraPool HLM 150 pool is statistically modeled so that lot-to-lot variability represented as coefficient of variation (CV) is <10% (mean) for the more variable CYP enzyme (CYP2C19), and <5% (mean) for the key drug metabolizing CYPs (CYP1A2, CYP2C9, CYP2D6 and CYP3A4). This lot-to-lot consistency is critical for researchers to achieve data consistency for metabolic stability, CYP inhibition and reaction phenotyping assays year after year with multiple HLM lots.
Learn more »Antibodies Against Drug Metabolizing Enzymes
BD Supersomes Recombinant Drug Metabolizing Enzymes and Controls
- Animal Cytochrome P450 Enzymes
- Control Supersomes Enzymes, NADPH, UDPGA and Incubation Buffers
- Fluorometric Cytochrome P450 Inhibition Kits
- Human Cytochrome P450 Enzymes
- UGT and Other Metabolic Enzymes
Enzyme Substrates, Inhibitors, Metabolite Standards, Cofactors and Buffers
- Cytochrome P450 and UGT Substrates, Metabolite Standards and Inhibitors
- Fluorometric Substrates and Associated Metabolite Standards
- NADPH, UDPGA and Incubation Buffers
- Stable Isotope Labeled Reference Metabolites
Lymphoblast Expressed Enzymes
Primary Hepatocytes
- Animal CryoHepatocytes
- Hepatocyte Purification and Culture
- Human CryoHepatocytes
- Human Fresh Hepatocytes
Tissue Fractions
- Animal Liver Microsomes, S9, and Cytosol
- Human Pooled Liver Microsomes, S9, and Cytosol
- Human Single Donor Liver Microsomes Including Allelic Variants
- NADPH, UDPGA and Incubation Buffers
- Tissue Fractions Prepared From Extrahepatic Tissue
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
