In Vitro Drug Metabolism Literature
These references have been selected from the scientific literature as
examples of in vitro drug metabolism methods or general information
about cytochrome P450.
Journal Articles
The
Use of Heterolously Expressed Drug Metabolizing Enzymes -- State of the
Art and Prospects for the Future.
Crespi, CL, and VP Miller. 1999, Pharmacol. Ther., 84:121-131.
In
Vitro Assessment of Human Cytochrome P450.
SE Clarke. 1998, Xenobiotica 28(12):1167-1202.
Identification
of Cytochrome P450 Enzymes Involved in the Metabolism of Zotepine, an
Antipsychotic Drug, in Human Liver Microsomes.
Shiraga, T, Kaneko, H, Iwasaki, K, Tozuka, Z, Suzuki, A, and T Hata. 1999,
Xenobiotica 29(3): 217-229.
These papers review the RAF and RSF approach to designing experiments
and interpreting data using cDNA-expressed enzymes.
Development
of a Substrate-Activity Based Approach to Identify the Major Human Liver
P450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on
cDNA-Expressed Activities and Liver Microsomal P450 Profiles.
Roy, P, Yu, LJ, Crespi, CL, and DJ Waxman. 1999, Drug Metab. Dispos.
27(6):655-666.
Azelastine
N-demethylation by Cytochrome P-450 CYP3A4, CYP2D6, and CYP1A2 in Human
Liver Microsomes: Evaluation of an Approach to Predict the Contribution
of Multiple CYPs.
Nakajima, M, Nakamura, S, Tokudome, S, Shimada, N, Yamazaki, H, and Yokoi,
T, (1999) Drug Metab. Dispos., 27, 1381-1391.
Use
of cDNA-Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug
Interactions, Crespi, CL and BW Penman, (1997) Adv. Pharmacol.
43, 171-188.
Books
Cytochrome P450 Protocols.
Phillips, IR and EA Shepard, eds. 1998. Methods in Molecular Biology Vol.
107, Humana Press.
Introduction to Drug Metabolism.
Gibson, GG and P Skett. 1994, Blackie Academic & Professional.
Cytochromes P450 -- Metabolic and Toxicological Aspects
C Ioannides, ed. 1996, CRC Press.
Cytochrome P450 -- Structure, Mechanism, and Biochemistry.
PR Ortiz de Montellano, ed. 1995, Plenum Press.
|
