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BD Gentest™ Posters
Hepatocytes
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| Characterization of a Four-donor Pool of Cryopreserved
Human Hepatocytes for Metabolic Stability Studies |
PDF |
| Comparison of the Metabolic Profile of
Various Substrates: The Effect of Species and Methodology |
PDF |
| Validation of Pooled Cryopreserved Human Hepatocytes
as a Model for Metabolism Studies |
PDF |
| Effect of Long-Term Culture on Cytochrome P4503A Induction
in Primary Cultured Human Hepatocytes |
PDF |
| Comparison of Major Phase I and Phase II Metabolism
Reactions in Cryopreserved Dog and Human Hepatocytes |
PDF |
| Validation of Cryopreserved Human Hepatocytes
for use in P450 Induction Studies |
PDF |
| Analysis of P450 Induction Potential in BD Gentest™
Cryopreserved Hepatocytes |
PDF |
Solubility Scanner
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| Aqueous Solubility by Flow Cytometry II:
New Prototypes Optimized for Drug Solubility Testing |
PDF |
| A New Method for Detecting and Characterizing Compound
Aggregates to Improve the Accuracy of In-Vitro Screens |
PDF |
| Maximizing Compound Solubility in Drug Development (Poster provided by Roche) |
PDF |
| A Fully Automated Workstation for Testing Flow-Based Kinetic Solubility of Compounds |
PDF |
Fluorescent P450 Assays
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| Role of 3A5 and 3A7 in Drug-Drug Interactions |
PDF |
| Cytochrome P450 Fluorometric Substrates:
Identification of Isoform-Selective Probes for Rat CYP2D2, CYP2D6
and Human CYP3A4 |
PDF |
| Substrate Dependent Effects on CYP3A4 Inhibition
or Activation by 27 Test Compounds |
PDF |
| Human and Rat Cytochrome P450 Isoform Selectivity
within a Panel of Fluorometric Substrates |
PDF |
| Novel High Throughput Methods With cDNA-Expressed
Enzymes |
PDF |
| Novel High Throughput Fluorescent P450
Assays |
PDF |
| Fluorometric Cytochromes P450 2C8, 2C9,
and 2C19 Inhibition Assays: Testing the One Substrate Paradigm |
PDF |
Transporters
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Human Organic Anion Transporting Polypeptide
8 Polymorphisms: Identification and
Characterization of a Novel hOATP8 Isoform |
PDF |
| BD Gentest™ Tranportocytes: Peptide Transporters
and Organic Anion Transporters |
PDF |
| Using LC/MS for Detection of Estrone 3-SulfateTransport
by Human OATP2 Expressed in Xenopus Oocytes |
PDF |
| Expression of Transporters in Xenopus Laevis Oocytes |
PDF |
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Heterologous Expression of and the Development of Assays for Interaction
of Drugs With Human P-Glycoprotein (PGP)
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PDF |
Cell-Based Toxicity Assays
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| Rapid Analysis of Hepatocyte Toxicity |
PDF |
| A Rapid Homogenous Method for Metabolic
Toxicity Screening |
PDF |
| Detection of Metabolic Toxicity in a Homogeneous
Cellular Assay |
PDF |
| Early Detection of CYP Specific Toxicity |
PDF |
| A High Throughput Method for Detection
of Toxic P450-Dependent Metabolites |
PDF |
| A High Throughput, Cell-Based Assay for
Metabolic Toxicity |
PDF |
Human UDP Glucuronosyl Transferases
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| Glucuronidation of (R,R)-Formoterol and
(S,S)-Formoterol is Catalyzed by cDNA-expressed Human Uridine 5´-Diphospho-Glucuronosyltransferases
and Human Liver Microsomes |
PDF |
| Cytochromes P450, UDP-Glucuronosyltransferases
and Carboxylesterases In Human Small Intestine Microsomes: Characterization
and Inter-Individual Variability Among Donors |
PDF |
| Effect of Common Organic Solvents on Human Uridine
5’-Diphospho-Glucuronosyltransferase (UGT) Enzyme Activities |
PDF |
| Characterization of a Probe Substrate and
an Inhibitor of UDP Glucuronosyl Transferase (UGT) 1A4 Activity in
Human Liver Microsomes (HLM) and cDNA-Expressed UGT-Enzymes |
PDF |
| A Sensitive Fluorometric High Throughput
Inhibition Assay for Human UDP Glucuronosyl Transferase (UGT) 1A1 |
PDF |
| Analysis of UGT Enzyme Levels
in Human Liver Microsomes Using Form Specific Anti-Peptide Antibodies,
Probe Substrate Activities and Recombinant UGT Enzymes |
PDF |
| Heterologous Expression of Human UDP Glucuronosyl
Transferases |
PDF |
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Heterologous Expression of Human UDP Glucuronosyl Transferases:
UGT 1A1, 1A4, 1A6, 1A9, 2B7 AND 2B15
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PDF |
Human Monoamine Oxidases
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| Fluorescent-Based, High Throughput
Assay for Detecting Inhibitors of Monoamine Oxidase A and B |
PDF |
Aromatase (CYP19)
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| Aromatase Inhibition by Azole Drugs: Assessing Pregnancy
Risks |
PDF |
| Assessing Pregnancy Risks of Azole Antifungals Using
a High Throughput Aromatase Inhibition Assay |
PDF |
| A High Throughput Screen to Identify Inhibitors
of Aromatase (CYP19) |
PDF |
| CYP19 (Aromatase): Characterization of
the Recombinant Enzyme and Its Role in the Biotransformation of Xenobiotics |
PDF |
Other Topics
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| Validation of a Phase I and Phase II Metabolic
Stability Assay in Subcellular Fractions |
PDF |
| Inter-Individual Variability in Cytochromes
P450 Activity in a Large Bank of Human Liver Microsomes |
PDF |
| Heterologous Expression of Various Animal P-Glycoprotein
using the Insect Cell-Baculovirus Expression System |
PDF |
| Evidence of Mechanism-Based Inhibition by the Highly
Selective Human CYP3A Inhibitor Azamulin |
PDF |
| Comparison of Human Liver Microsomes and cDNA-Expressed
Enzymes in Cytochrome P450 Inhibition Studies |
PDF |
| CYP2J2 and CYP4F12 are Active for the Metabolism
of Non-Sedating Antihistamines: Terfenadine and Astemizole |
PDF |
| Azamulin is Superior to Ketoconazole as
a Selective CYP3A Inhibitor Probe |
PDF |
| Potential Caveats of Reaction Phenotyping
with High Concentrations of Human Liver Microsomes: The Example of
R-Warfarin |
PDF |
| Metabolic Stabilty of CYP Isoform Selective
Inhibitors in the Presence of Human Liver Microsomes |
PDF |
| Heterologous Expression of Human Cytochrome
P450 4F3 Using the Insect Cell-Baculovirus Expression System |
PDF |
| Effect of Salt Concentration on the Activity
of Liver Microsomal and cDNA-Expressed Human Cytochromes P450 |
PDF |
| Characterization of Antibodies With Selective
Recognition of Human Flavin-Containing Monooxygenases on Immunoblots |
PDF |
| Characterization of Antibodies With Selective
Recognition of Cytochrome P450s on Immunoblots |
PDF |
| Characterization of cDNA-Expressed Rat
P450 Enzymes in Microsomes Prepared From Baculovirus Infected Insect
Cells (BD Supersomes™ Enzymes) |
PDF |
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