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High Throughput P450 Inhibition Kits

Fluorescent P450 Substrates, Metabolite Standards, and Inhibitors

The following cytochrome P450 substrates, metabolites, and chemical inhibitors are recommended for use in high throughput screening methods for cytochrome P450 inhibition. Some of these chemicals are manufactured by SAFC and are distributed by BD Gentest in the U.S.A. and Canada.
Chemicals in light blue (Cat. # Bxxx) are manufactured by BD Gentest and are available worldwide.

Product Catalog Number Size Use
AMMC 451700 (Old B700)   5 mg Fluorescent CYP2D6 Substrate
AMMC 451705 (Old B705) 25 mg Fluorescent CYP2D6 Substrate
AHMC 451701 (Old B701)   5 mg AMMC Metabolite Standard
7-Benzyloxyquinoline (BQ)* 451720 (Old B720)   5 mg Fluorescent CYP3A4 Substrate
7-Benzyloxyquinoline (BQ)* 451725 (Old B725) 25 mg Fluorescent CYP3A4 Substrate
7-Benzyloxy-4-(trifluoromethyl)-coumarin (BFC) 451730 (Old B730)   5 mg Fluorescent CYP3A4 Substrate
7-Benzyloxy-4-(trifluoromethyl)-coumarin (BFC) 451735 (Old B735) 25 mg Fluorescent CYP3A4 Substrate
3-Cyano-7-ethoxycoumarin (CEC) UC-455 10 mg Fluorescent P450 Substrate
3-Cyano-7-methoxycoumarin (CMC) UC-454 10 mg Fluorescent P450 Substrate
DBF 451750 (Old B750) 5 mg Fluorescent CYP2C8, CYP2C9, CYP2C19, and CYP3A4 Substrate
DBF 451755 (Old B755) 25 mg Fluorescent CYP2C8, CYP2C9, CYP2C19, and CYP3A4 Substrate
Furafylline 451165 (Old UC-165) 5 mg CYP1A2 Mechanism-based Inhibitor
HAMC 451761 (Old B761) 5 mg MAMC Metabolite Standard
7-hydroxyquinoline 451721 (Old B721) 5 mg BQ Metabolite Standard
7-Hydroxy-4-(trifluoromethyl)-coumarin (7-HFC) 451731 (Old B731) 5 mg BFC, EFC, MFC Metabolite Standard
MAMC 451760 (Old B760) 5 mg Fluorescent CYP2D6 Substrate
MAMC 451765 (Old B765) 25 mg Fluorescent CYP2D6 Substrate
7-Methoxy-4-(trifluoromethyl)-coumarin (MFC) 451740 (Old B740) 5 mg Fluorescent CYP2C9 Substrate
7-Methoxy-4-(trifluoromethyl)-coumarin (MFC) 451745 (Old B745) 25 mg Fluorescent CYP2C9 Substrate
Ketoconazole UC-280 5 mg CYP3A4 Inhibitor
Sulphaphenazole 451166 (Old UC-166) 5 mg CYP2C9 Inhibitor

 

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