Clinical Research

Powerful tools to study Tregs, cytokines, and markers of suppression.

Transplantation is a life-saving procedure for many pathological conditions. Control of the immune system is essential for the prevention of tissue graft rejection. Immune suppression can make patients more vulnerable to infection. In a bone marrow transplant, a new immune system is reconstituted. However, if the transplanted bone marrow is not matched, it can lead to the immune system attacking the host, or graft-versus-host disease (GVHD).


BD Biosciences has many tools to assist in transplantation research that include markers of stem cell differentiation such as CD34 and hematopoietic stem cell identification and isolation kits, as well as tools for the study of cellular immunity such as effector and regulatory T cell markers.

References

Fischer JC, Ottinger H, Ferencik S, et al. Relevance of C1 and C2 epitopes for hemopoietic stem cell transplantation: role for sequential acquisition of HLA-C-specific inhibitory killer Ig-like receptor. J Immunol. 2007;178:3918-3923. 

Golshayan D, Jiang S, Tsang J, Garin MI, Mottet C, Lechler RI. In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance. Blood. 2007;109:827-835.

Chakraverty R, Flutter B, Fallah-Arani F, et al. The host environment regulates the function of CD8+ graft-versus-host-reactive effector cells. J Immunol. 2008;181:6820-6828. 

Gondek DC, Devries V, Nowak EC, et al. Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells. J Immunol. 2008;181:4752-4760.