Clinical Research

Leading-edge inflammatory cytokine and chemokine detection assays.

Autoimmunity is the failure of an organism to recognize its own constituent parts as self, which results in an immune response against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease. Prominent examples include multiple sclerosis (MS), rheumatoid arthritis (RA), Crohn’s disease, type I diabetes, and lupus. BD Biosciences supports autoimmune clinical research with a broad range of reagents for flow cytometry applications to help scientists understand the intricacies of human immune function. This research area has given rise to many exciting new areas of study, such as Th17 and regulatory T cells (Tregs), that may hold important clues to our understanding of autoimmunity-related diseases.


Products for Multiple Sclerosis Research

MS, also known as disseminated sclerosis or encephalomyelitis disseminata, is an autoimmune condition in which the immune system attacks the central nervous system, leading to demyelination. It has been reported that MS patients may have a reduced number of whole (or subsets of) regulatory T cells, (such as CD39 positive) and abnormal levels of Th17 cells.

References

Melzer N, Meuth SG, Torres-Salazar D, et al. A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis. PLoS One. 2008;3:e3149.


Products for Lupus Research

Lupus is an autoimmune disease with B-cell hypereactivity and defective T-cell function. BD Biosciences carries several tools for the study of lupus including antibodies to CD20 and CD22 for the study of B cells. For the study of T cells, BD Biosciences carries antibodies, cocktails, and kits specific to regulatory, Th17, and other T cells.

References

Mehrad B, Park SJ, Akangire G, et al. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol. 2006;176:3233-3239.

Sharabi A, Luger D, Ben-David H, Dayan M, Zinger H, Mozes E. The role of apoptosis in the ameliorating effects of a CDR1-based peptide on lupus manifestations in a mouse model. J Immunol. 2007;179:4979-4987.


Products for Crohn’s Disease Research

Crohn’s disease is an autoimmune disease of the gastrointestinal tract resulting in inflammation, abdominal pain, and weight loss. While the exact defect in immune function is not yet defined, several have been proposed including over-reactive-Th1 cytokine response, impaired innate immunity, and defects in Th17. Active Crohn’s disease has been associated with increases in IL-17F gene expression. Tools for the study of Crohn’s disease include kits to measure cytokine levels (CBA), antibodies to cytokines, and antibodies, kits, and cocktails for the phenotyping of T cells.


Products for Arthritis Research

RA is a chronic inflammatory disease characterized by joint inflammation and bone and cartilage erosion. Cytokines produced by infiltrating activated macrophages and T cells are involved in osteoclast-mediated bone resorption. Using BD Biosciences antibodies and kits including antibodies to cytokines and T-cell markers, infiltrating cells such as Th17 and regulatory T cells can be identified and cytokine levels can be measured.

References

Rankin AL, Reed AJ, Oh S, et al. CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritis. J Immunol. 2008;180:833-841.